Brn-3.2: A Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid

doi:10.1016/0896-6273(94)90164-3

Neuron

Volume 12, Issue 1, January 1994, Pages 205-218

https://doi.org/10.1016/0896-6273(94)90164-3 Get rights and content

Abstract

The identification and molecular characterization of Brn-3.2 has revealed a family of Brn-3-related mammalian POU proteins that share homology with the C. elegans developmental regulator Unc-86 and extended similarity with the Drosophila neurodevelopmental gene I-POU, which defines a novel POU-IV box. Brn-3.2 exhibits DNA binding properties similar to those of Brn-3.0, but its expression is uniquely regulated by retinoic acid in teratocarcinoma and neuroblastorna cells. In the developing PNS and retina, the expression pattern of Brn-3.2 is similar to that of Brn-3.0. In the caudal CNS (spinal cord, hindbrain, and midbrain) Brn-3.2 and Brn-3.0 are initially coexpressed, but diverge later in development. Rostral to the midbrain, Brn-3.2 and Brn-3.0 exhibit nonoverlapping patterns of expression, suggesting divergence of gene function in more recently evolved structures. Our analysis suggests that in the CNS Brn-3.2 is selectively expressed in postmitotic neurons, implying a role in specifying terminally differentiated neuronal phenotypes.

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Neuron

ArticleBrn-3.2: A Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid

Abstract

Cell

Cell

Cell

Neuron

Cell

Neuron

Neuron

Neuron

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis

Genes Dev.

Development of the cranial nerve ganglia and related nuclei in the rat

Adv. Anat. Embryol. Cell Biol.

The development of the rat spinal cord

Adv. Anat. Embryol. Cell Biol.

Development of the precerebellar nuclei in the rat: II.The intramural olivary migratorystream and the neurogenetic organization of the inferior olive

J. Comp. Neurol.

Development of the precerebellar nuclei in the rat: IV. The anterior precerebellar extramural migratory stream and the nucleus reticularis tegmenti pontis and the basal pontine gray

Comp. Neurol.

Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous system

Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons

Science

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6

Nature

Oct-2, although not required for B-cell development, is critical for later B-cell maturation and postnatal survival

Genes Dev.

Solution structure of the POUspecific DNA-binding domain of Oct-1

Nature

A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons

Nature

The generation of neuronal diversity in the Drosophila embryonic central nervous system

Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells

Genes Dev.

Brn-3.0: a POU domain protein expressed in the sensory, immune, and endocrine systems that selectively functions on non-octamer motifs

NSCL-2: a basic domain helix-loop-helix gene expressed in early neurogenesis

Cell Growth Diff.

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis

EMBO J.

The development of the vertebrate retina: a comparative survey

Adv. Anat. Embryol. Cell Biol.

Retinoic acid and teratocarcinoma stem cells

Semin. Dev. Biol.

Structure and evolution of four POU domain genes expressed in mouse brain

Expression of a large family of POU domain genes in mammalian brain development

Nature

Tst-1, a member of the POU domain gene family, binds to a promoter of the gene encoding the cell surface adhesion molecule P0

Mol. Cell. Biol.

Homeobox genes and models for patterning the hindbrain and branchial arches

Development (Suppl.)

Article
Brn-3.2: A Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid

Tst-1, a member of the POU domain gene family, binds to a promoter of the gene encoding the cell surface adhesion molecule P₀