Neuron
TAG-1 can mediate homophilic binding, but neurite outgrowth on TAG-1 requires an L1-like molecule and β1 integrins
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Cited by (174)
Members of the vertebrate contactin and amyloid precursor protein families interact through a conserved interface
2022, Journal of Biological ChemistryCitation Excerpt :Interactions are detected using AlphaScreen technology in which a luminescent signal is emitted when a target protein fused to the FcY-Twin-Strep tag (designated FcYTS) bound to a streptactin donor bead associates with another target protein fused to IgG Fc attached to a protein A acceptor bead (protein A does not bind to the Fc region of IgY (30)) (Fig. 2C). To validate our methodology, we first monitored the self-association of CNTN2, which forms homodimers and used gamma-aminobutyric acid type B receptor subunit 1 (GABBRI) and protein tyrosine phosphatase receptor type G (PTPRG) as positive controls for interactions with APP and CNTN3–6, respectively (31–35). We detected interactions between the pairs CNTN2-Fc/CNTN2-FcYTS, APP-Fc/GABBRI-FcYTS, APP-FcYTS/GABBRI-Fc, PTPRG-Fc/CNTN3-6-FcYTS, and PTPRG-FcYTS/CNTN3-6-Fc (Figs. 2D and S1, C and D).
Immunoglobulin cell adhesion molecules of the Ig-FNIII type and neurodevelopment
2021, Factors Affecting Neurodevelopment: Genetics, Neurology, Behavior, and DietThe role of Gpi-anchored axonal glycoproteins in neural development and neurological disorders
2017, Molecular and Cellular NeuroscienceCitation Excerpt :As noted above, CNTN2 can bind homophilically to cause cell and bead aggregation (Felsenfeld et al., 1994; Rader et al., 1993; Yamagata and Sanes, 2012), which is not true of CNTN1 which instead binds heterophilically (see Fig. 2). However, it is unclear whether homophilic binding occurs in cis or trans (Mortl et al., 2007) and several studies indicate that CNTN2 neurite outgrowth stimulation critically involves heterophilic interactions with other CAMs, including ß1 integrins, L1/NgCAM and NrCAM (Kuhn et al., 1991; Felsenfeld et al., 1994; Stoeckli et al., 1997; Lustig et al., 1999). Thus, both CNTN1 and CNTN2 stimulate axon growth using heterophilic interactions.
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Present address: Genentech, Inc., 460 Point San Bruno Boulevard, South San Francisco, California 94080.
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Present address: Laboratory of Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London, England.