European Journal of Pharmacology: Molecular Pharmacology
Short communicationNeurotensin stimulates cyclic AMP formation in CHO-rNTR-10 cells expressing the cloned rat neurotensin receptor
References (13)
- et al.
Neurotensin stimulates inositol phospholipid hydrolysis in rat brain slices
Brain Res.
(1984) - et al.
Protein measurement with the Folin phenol reagent
J. Biol. Chem.
(1951) - et al.
Effect of vasoactive intestinal peptide (VIP) and other peptides on cAMP accumulation in rat brain
Biochem. Pharmacol.
(1978) - et al.
Interaction of neuropeptides and biogenic amines on cyclic adenosine monophosphate accumulation in hypothalamic nuclei
Brain Res.
(1986) Pharmacology and second messenger interactions of cloned muscarinic receptors
Biochem. Pharmacol.
(1991)- et al.
Structure and functional expression of the cloned rat neurotensin receptor
Neuron
(1990)
Cited by (47)
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
2017, European Journal of PharmacologyCitation Excerpt :Moreover, the use of UBOQIC, a Gαq blocker (Inamdar et al., 2015) completely abolished the NT-induced increase in inositol phosphate formation (Fig. 2B), thus reinforcing the point that NT-induced calcium release is mediated solely through Gαq activation. Since NTS1 was found to potentiate the adenylyl cyclase-dependent production of cAMP through Gαs activation (Skrzydelski et al., 2003; Yamada et al., 1993), we evaluated the ability of these three NTS1 ligands to produce cAMP over a 30-min stimulation period (Fig. 2C). All three ligands elevated the cAMP levels, but no differences were observed for the three compounds with respect to their EC50 values (Table 2).
Label-free cell phenotypic profiling and pathway deconvolution of neurotensin receptor-1
2016, Pharmacological ResearchCitation Excerpt :Several signaling pathways after NT stimulation are potentially involved in proliferation, survival, migration, and invasion processes of cancer cells. For example, NT activated NTS1 in KM20 cells, resulted in Ca2+- and mitogen-activated protein kinase (MAPK) signaling pathways [17], while the activation of NTS1 in N1E115 cells resulted in cGMP [18,19] and phospholipase C (PLC) activation [20,21]. In human prostate cancer cell line PC3, the activation of NTS1 by NT transactivates epidermal growth factor receptor (EGFR), an important receptor in cancer progression [22].
The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers
2011, BiochimieCitation Excerpt :Coupling with other heterotrimeric G-proteins, such as Gαi/0 and Gαs, is equally mentioned in the literature. The activation of Gαi/0 was mainly described in neuronal cells, whereas activation of Gαs was seen in NTSR1-transfected cells, suggesting that coupling occurs when NTSR1 is over-expressed in the cells [64,65]. Several signaling pathways potentially induced and involved in cellular proliferation, survival, migration, and invasion processes are described after NTS stimulation.