Structure, diversity and synaptic localization of inhibitory glycine receptors
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Cited by (39)
Synaptic changes underlying the strengthening of GABA/glycinergic connections in the developing lateral superior olive
2010, NeuroscienceCitation Excerpt :In the anteroventral cochlear nucleus larger glycine receptor cluster size correlate with larger mIPSC amplitudes (Lim et al., 1999). In the spinal cord and other brain areas, a developmental switch of glycine receptor subunit has been observed, where initially α2 subunit is predominant, but later replaced by α1 subunit (Betz et al., 1994). At least in the rat LSO, this switch does not seem to occur because the level of mRNA for α2 subunit is very low at birth and remains low, while α1 mRNA level increases during the first two postnatal weeks (Piechotta et al., 2001).
Age-related changes in glycine receptor subunit composition and binding in dorsal cochlear nucleus
2009, NeuroscienceCitation Excerpt :The significant age-related decreases of GlyR α1 and α2 protein staining of fusiform cells in middle and high frequency areas of DCN may correlate directly with the loss of strychnine binding sites (Fig. 6), consistent with previous rat and mouse aging studies (Frostholm and Rotter, 1985, 1986; Glendenning and Baker, 1988; Milbrandt and Caspary, 1995). Strychnine receptor binding is thought to be α1 sensitive and binds to the interface between α and β subunits (Young and Snyder, 1973, 1974; Betz et al., 1994; Schmieden and Betz, 1995; Legendre, 2001; Grudzinska et al., 2005). Thus, strychnine binding depends on the presence of these two subunits (Milbrandt and Caspary, 1995; Krenning et al., 1998).
Astrocytic receptors and second messenger systems
2003, Advances in Molecular and Cell BiologyCitation Excerpt :Functional glycine receptors have been detected on astrocytes. These receptors mediate a Cl− conductance (Betz et al., 1994) and show similarities with the GABAA receptor. The monoamines noradrenaline and dopamine share a common biosynthetic pathway that starts with the amino acid tyrosine.
Why glycine transporters have different stoichiometries
2002, FEBS Letters