Gene therapy: adenovirus vectors
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2023, Drug Discovery TodayDevelopment of a recombinant adenovirus-vectored vaccine against both infectious hematopoietic necrosis virus and infectious pancreatic necrosis virus in rainbow trout (Oncorhynchus mykiss)
2023, Fish and Shellfish ImmunologyCitation Excerpt :Replication-defective recombinant adenoviruses are extensively used as vectored vaccines for mammalian pathogens [31–36]. The best advantage of replication-defective recombinant adenovirus vectors is that they can efficiently transfer target genes into host cells by immersion vaccination inducing potent and sustained specific humoral and cellular immune responses, but the transferred target genes are not required to be integrated into host genome [32,37]. Interestingly, several kinds of teleost cell lines, including rainbow trout cells can be infected by a recombinant adenovirus [38].
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