Original articleChanges in emotional behavior produced by long-term amygdala kindling in rats
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The effect of left and right long-term amygdala kindling on interictal emotionality and Fos expression
2020, Epilepsy and BehaviorCitation Excerpt :Interestingly, plasma corticosterone response to the elevated plus maze correlates highly and positively with stretched-attended behaviors suggesting that this measure may be associated with the levels of anxiety [42]. Third, while earlier studies have observed that long-term kindled rats exhibit higher levels of open arm activity in the elevated plus maze, these rats often engage in greater escape-related behaviors, such as jumping behavior, from the apparatus [21]. Although we did not measure jumping behavior in this experiment, we did notice that kindled rats displayed greater stress-related piloerection during behavioral testing suggesting that the increased activity in the elevated plus maze might be anxiety- or escape-driven.
Tests of unconditioned anxiety - Pitfalls and disappointments
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This work was supported by NSERC grants to J.P.J. Pinel and D. Treit and by a Medical Research Council of Canada Scholarship to L.E. Kalynchuk.