Research reportLocalization of brain angiotensinogen mRNA by hybridization histochemistry
References (19)
- et al.
Colocalization of angiotensinogen and glial fibrillary acidic protein in astrocytes in rat brain
Brain Research
(1986) - et al.
Intraventricular angiotensin II increases brain vascular permeability
Brain Research
(1981) - et al.
Tissue distribution of rat angiotensinogen mRNA and structural analysis of its heterogeneity
J. Biol. Chem.
(1986) - et al.
In situ hybridization for the study of gene expression in the brain
Meth. Enzymol.
(1986) - et al.
Common structural organization of the angiotensinogen and the alpha-1-antitrypsin genes
J. Biol. Chem.
(1984) - et al.
Neurogenic mechanisms of experimental hypertension
- et al.
Identity of angiotensinogen precursors of rat brain and liver
Nature (London)
(1984) - et al.
Glucocorticoid-sensitive vasopressin mRNA synthesis in the paraventricular nucleus of the rat
- et al.
Angiotensin synthesis in the brain and increased turnover in hypertensive rats
Science
(1983)
Cited by (108)
Renin-Angiotensin-Aldosterone System
2022, Comprehensive PharmacologyFluid intake, what's dopamine got to do with it?
2021, Physiology and BehaviorCitation Excerpt :One mechanism by which dopamine controls fluid intake is through interactions with the renin-angiotensin system. Indeed, the angiotensin type 1 receptor (AT1R) and the components to synthesize endogenous angiotensin II (AngII), including angiotensinogen and angiotensin converting enzyme, are expressed within the mesolimbic and nigrostriatal pathways [73-78]. In vitro studies in striatal slices demonstrate that AngII stimulates dopamine release [79] and dopamine metabolite levels are increased by AngII or decreased by AT1R antagonist treatment, respectively [80].
Angiotensinergic receptors in the medial amygdaloid nucleus differently modulate behavioral responses in the elevated plus-maze and forced swimming test in rats
2021, Behavioural Brain ResearchCitation Excerpt :Angiotensin-immunoreactive terminals, angiotensin II binding sites and expression of all angiotensin receptors were identified within the MeA [47–50]. Besides, the MeA seems to have the highest level of angiotensinogen within the amygdaloid complex [51]. However, it remains to be addressed the involvement of angiotensinergic receptors present within the MeA in control of anxiety- and depressive-like behaviors.
The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: Insight from preclinical stroke studies and therapeutic potential
2020, Cellular SignallingCitation Excerpt :The angiotensinergic neurons project to the paraventricular nucleus, supraoptic nucleus and the nucleus of the solitary tract [64,65] which are all neural circuits involved in fluid regulation, vasopressin release, sympathetic innervation and thirst response [66]. Furthermore, expression of the RAS components has been demonstrated within the brain, with renin activity demonstrated in the brain independent of circulating renin [67], angiotensinogen mRNA detected across the rat brain [68] and in both astrocytes [69] and neurons [70], ACE detected by radioligand binding in various regions of the human brain [71], and detection of Ang II and other angiotensin peptides (including Ang-(1–9) and Ang-(1–7)) in rat and sheep brains [72]. Following the discovery of ACE2, its expression was also confirmed within the brain at both a mRNA and protein level [73], and expression of the RAS receptors, AT1R, AT2R and Mas receptor, in the brain have been demonstrated by numerous studies [74–83].
Beneficial effects of Angiotensin II receptor blockers in brain disorders
2017, Pharmacological ResearchCitation Excerpt :Validated evidence for the presence of brain Angiotensinogen and ACE was provided by in situ hybridization and quantitative autoradiography [2–5]. Surprisingly, brain ACE and Angiotensinogen were found to be localized in separate cells; Angiotensinogen was predominantly or exclusively expressed in glial cells located in many brain structures, while ACE was predominantly expressed in the choroid plexus and the caudate nucleus and has, additionally, a predominant endothelial localization [1–7]. In the subfornical organ, in situ hybridization of Angiotensin II AT1 receptors was restricted to neurons, while Angiotensinogen was localized in glial cells [3].