Persistence of nonphotic phase shifts in hamsters after serotonin depletion in the suprachiasmatic nucleus
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Cited by (52)
Biological timekeeping
2012, Sleep Medicine ClinicsCitation Excerpt :Forced wheel-running or sleep deprivation during the day also increases 5-HT in the SCN,66,67 which suggests a role for 5-HT in nonphotic phase-shifting. However, depleting 5-HT from raphe projections does not prevent this nonphotic daytime shift,68 and serotonergic antagonists are not able to attenuate this phase shift,69 providing mixed evidence for the role of 5-HT. This finding suggests modulation by additional messengers, possibly neuropeptides.
Feedback actions of locomotor activity to the circadian clock
2012, Progress in Brain ResearchCitation Excerpt :Neurotoxic lesions of serotonin neurons in the MR, which result in complete depletion of serotonin fibers in the SCN, have been reported to block triazolam-induced but not novel wheel-induced shifts (Meyer-Bernstein and Morin, 1998). Moreover, other studies have found serotonin depletion in the SCN and serotonin antagonist injections to neither attenuate phase shifts resulting from novelty-induced wheel-running (Antle et al., 1998; Bobrzynska et al., 1996b) nor alter the acceleration of reentrainment mediated by wheel-running (Smale et al., 1990). However, Bobrzynska et al. (1996b) report only 88–95% depletion of serotonin in and around the SCN and the serotonergic DR projection to the IGL, and IGL projection to the SCN, would have been intact in this study and may account for the failure to block shifts.
Circadian clock resetting by behavioral arousal: neural correlates in the midbrain raphe nuclei and locus coeruleus
2010, NeuroscienceCitation Excerpt :However, localized SCN administration of serotonin agonists has little (Challet et al., 1998; Ehlen et al., 2001) or no (Mintz et al., 1997; Antle et al., 2003) phase shifting effect in vivo, unless the SCN are first depleted of 5HT by neurotoxin (Ehlen et al., 2001) or by isolation in vitro (Prosser et al., 2006), or the circadian system is altered in some yet to be clarified way by exposure to bright constant light for 1–3 days (Knoch et al., 2004; Duncan et al., 2005). Also, phase shifts in hamsters induced by stimulated running are not blocked by 5HT receptor antagonists or by 5HT ablation (Bobrzynska et al., 1996; Antle et al., 1998, 2000; Meyer-Bernstein and Morin, 1998), indicating that clock resetting by behavioral procedures does not require a direct serotonergic pathway from the MnR to the SCN. Other results suggest that 5HT participates in phase shifts to behavioral stimuli primarily via a DRN to IGL to SCN pathway, with the IGL assuming a critical role as gateway for non-photic phase shifts.
Functional neuroanatomy of sleep and circadian rhythms
2009, Brain Research ReviewsCitation Excerpt :Arousal, wakefulness and motor activity are all associated with increased forebrain serotonin release (Jacobs and Fornal, 1999), including in the SCN (Grossman et al., 2000; Mistlberger et al., 2000; Shioiri et al., 1991), and behavioral state-dependent serotonin release appears to at least partially mediate entrainment by scheduled daily locomotor activity and the effects of arousal on light-induced phase shifting (Edgar et al., 1997; Grossman et al., 2000; Marchant et al., 1997; Mistlberger and Antle, 1998; Mistlberger et al., 1998). In contrast, however, neither intra-SCN serotonin lesions, nor any of several serotonin receptor antagonists, inhibit circadian phase shifting by novelty-induced activity (Antle et al., 1998; Bobrzynska et al., 1996; Meyer-Bernstein and Morin, 1998). Several other chemically-identified pathways provide afferent input to the circadian system, including cholinergic projections from the basal forebrain and pontine tegmentum (Bina et al., 1993), noradrenergic projections from the brainstem (Cagampang et al., 1994; Moga and Moore, 1997), and histaminergic projections from the posterior hypothalamus (Panula et al., 1989; Wada et al., 1991).
Biological Timekeeping
2009, Sleep Medicine ClinicsCitation Excerpt :This suggests a possible link between 5-HT and nonphotic phase shifting, but evidence also exists to complicate this assertion. If 85% to 95% of the serotonin is depleted from the raphe projections to the SCN, animals still are capable of phase shifting in response to daytime forced activity.61 In addition, these activity-induced phase shifts are not attenuated significantly following injection of serotonergic antagonists.62