Elsevier

Brain Research

Volume 748, Issues 1–2, 14 February 1997, Pages 267-270
Brain Research

Short communication
Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats

https://doi.org/10.1016/S0006-8993(96)01383-2Get rights and content

Abstract

Ischemic tolerance was induced in spontaneously hypertensive rats (SHR) by injection of a single dose of lipopolysaccharide (LPS) (0.9 mg/kg, i.v.) 1–7 days prior to permanent middle cerebral artery occlusion (MCAO). Infarct volume, evaluated 24 h after MCAO, was significantly reduced by LPS administration 2, 3 or 4 days prior to MCAO (22.8, 25.9 and 20.5%, respectively). The beneficial effect of LPS pre-treatment was completely nullified by concurrent administration of TNFbp. On this basis, the tolerance to ischemia induced by LPS is likely to be mediated by TNF-α.

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Acknowledgements

We are grateful to Dr. Anna-Leena Sirén for measurement of serum TNF-α and to Karen Pettigrew for expert statistical consultation.

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