Elsevier

Brain Research

Volume 768, Issues 1–2, 12 September 1997, Pages 338-340
Brain Research

Short communication
Extracellular glutamate increases in the lateral hypothalamus and decreases in the nucleus accumbens during feeding

https://doi.org/10.1016/S0006-8993(97)00788-9Get rights and content

Abstract

Glutamate release was monitored in the lateral hypothalamus and the nucleus accumbens during a meal using 30 s resolution microdialysis and capillary zone electrophoresis with laser-induced fluorescence. A significant increase in hypothalamic glutamate and a decrease in accumbens glutamate were observed. These results, added to previous pharmacological studies, suggest that glutamatergic synapses in the lateral hypothalamus and the nucleus accumbens might be involved in the control of feeding behavior.

Section snippets

Acknowledgements

This research has been supported by CDCHT-ULA Grant M-551-95-03-A and BID-CONICIT Grant BTS-37.

References (11)

There are more references available in the full text version of this article.

Cited by (65)

  • A ketogenic diet modifies glutamate, gamma-aminobutyric acid and agmatine levels in the hippocampus of rats: A microdialysis study

    2017, Neuroscience Letters
    Citation Excerpt :

    A syringe loaded with FITC–carbonate mixture was placed in a precision pump, and 500 nl of the mixture was delivered into a 5 ul tube containing a microdialysis sample. The samples reacted overnight (14 h) at room temperature in a water-saturated chamber that minimized evaporation [25]. Microdialysis data was analyzed by Student’s t Test.

View all citing articles on Scopus
View full text