Short communicationM100907, a highly selective 5-HT2A receptor antagonist and a potential atypical antipsychotic drug, facilitates induction of long-term potentiation in area CA1 of the rat hippocampal slice
Section snippets
Acknowledgements
We thank Drs. Susan Patterson and Roberto Malinow for demonstrating the techniques of eliciting and analyzing LTP and for discussing the results, respectively. We also thank Hoechst Marion Roussel for providing M100907 and M100009. This research was supported by USPHS grants MH-41440.
References (24)
- et al.
NMDA-induced response in pyramidal neurons of the rat medial prefrontal cortex slices consists of NMDA and non-NMDA components
Brain Res.
(1997) - et al.
Voltage-clamp analysis of muscarinic excitation in hippocampal neurons
Brain Res.
(1982) - et al.
Cognitive enhancers and hippocampal long-term potentiation in vitro
Behav. Brain Res.
(1997) Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus
Neuron
(1991)- et al.
NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers
Neuropsychopharmacology
(1996) - et al.
The slow inhibitory postsynaptic potentials in rat hippocampal CA1 neurons is blocked by intracellular injection of QX-314
Neurosci. Lett.
(1990) - et al.
Recombinant BNF rescues deficits in basal synaptic transmission and hippocampal LTP in BNF knockout mice
Neuron
(1996) - et al.
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
Cell
(1996) - et al.
Effects of glycine and structurally related amino acids on generation of long-term potentiation in rat hippocampal slices
Eur. J. Pharmacol.
(1992) - et al.
The 5-HT3 receptor agonist 2-methyl-5-HT diminishes the efficacy of glutamatergic synaptic transmission in rat CA1 pyramidal neurons of the hippocampus in vitro
Brain Res.
(1994)
Quisqualate metabotropic receptors modulate NMDA currents and facilitate induction of long-term potentiation through protein kinase C
Eur. J. Neurosci.
Cited by (59)
Dopamine and serotonin interplay for valence-based spatial learning
2022, Cell ReportsCitation Excerpt :In contrast, 5-HT has been shown to induce long-term depression (LTD) for some receptor-specific hippocampal areas (Kemp and Manahan-Vaughan, 2004, 2005; Berumen et al., 2012; Wawra et al., 2014; Lecouflet et al., 2020). The effect of 5-HT in the hippocampus is still unclear since it has also been observed to produce LTP or metaplasticity regulation (Wang and Arvanov, 1998; Hagena and Manahan-Vaughan, 2017; Teixeira et al., 2018). Motivated by these experimental findings, we present a mathematical model of valence-based learning in the hippocampus, which details the antagonistic roles of DA and 5-HT for long-term synaptic plasticity.
Serotonin modulation of hippocampal functions: From anatomy to neurotherapeutics
2021, Progress in Brain ResearchAlteration level of hippocampus BDNF expression and long-term potentiation upon microinjection of BRL15572 hydrochloride in a rat model of methamphetamine relapse
2019, Brain Research BulletinCitation Excerpt :However, other study has shown have shown that the LTP produced in hippocampal slices is not influenced before and during exposure to this antagonist (NAN-190) (Maggio et al., 2018). Other reports indicated that LTP can be facilitated by 5-HT2A receptor antagonists (Wang and Arvanov, 1998) and 5-HT3 receptor antagonists (Staubli and Xu, 1995). However, given their enormous diversity, 5-HT receptors can have various effects on LTP.
Effect of a 5-HT<inf>1D</inf> receptor agonist on the reinstatement phase of the conditioned place preference test and hippocampal long-term potentiation in methamphetamine-treated rats
2018, Brain ResearchCitation Excerpt :The result of recordings from slices of guinea pig medulla indicated that release of serotonin inhibited by activation of presynaptic 5-HT1D receptor and electrophysiology recordings showed that use of 5-HT1D agonist (sumatriptan) inhibited the fEPSP creation (Bobker, 1994). In addition, studies have shown that 5-HT1A agonists do not affect LTP (Mori et al., 2001); however, LTP was facilitated using a 5-HT4 receptor agonist (Hagena and Manahan-Vaughan, 2017), and 5-HT2A (Mirjana et al., 2004; Wang and Arvanov, 1998) and 5-HT3 receptor antagonists (Bétry et al., 2011). As mentioned above, the effect of the METH on enhancement of serotonin release has been evaluated; however, it is not clear that the PNU142633 interacts directly with serotonin which releasing by METH or has a direct effect on the LTP.
Clozapine and GABA transmission in schizophrenia disease models: Establishing principles to guide treatments
2015, Pharmacology and Therapeutics