Elsevier

Brain Research

Volume 779, Issues 1–2, 1 January 1998, Pages 309-313
Brain Research

Short communication
M100907, a highly selective 5-HT2A receptor antagonist and a potential atypical antipsychotic drug, facilitates induction of long-term potentiation in area CA1 of the rat hippocampal slice

https://doi.org/10.1016/S0006-8993(97)01174-8Get rights and content

Abstract

In the present study, we have shown that M100907, a highly selective 5-HT2A receptor antagonist and a putative atypical antipsychotic drug (APD), markedly potentiates N-methyl-d-aspartate (NMDA) responses and excitatory postsynaptic currents (EPSCs) evoked by electrical stimulation of the Schaffer collaterals in CA1 hippocampal pyramidal cells. Furthermore, it enhances the induction of long-term potentiation (LTP) of CA1 synapses. If our findings can be extended to other atypical APDs, which are known to possess a relatively high affinity to 5-HT2A receptors, they may account for the purported efficacy of atypical APDs in alleviating some negative symptoms and improving cognitive and executive functions. In addition, the possibility of using M100907 as a nootropic should be further tested.

Section snippets

Acknowledgements

We thank Drs. Susan Patterson and Roberto Malinow for demonstrating the techniques of eliciting and analyzing LTP and for discussing the results, respectively. We also thank Hoechst Marion Roussel for providing M100907 and M100009. This research was supported by USPHS grants MH-41440.

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