Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine

doi:10.1016/S0014-2999(02)01291-8

European Journal of Pharmacology

Volume 438, Issues 1–2, 1 March 2002, Pages 115-116

https://doi.org/10.1016/S0014-2999(02)01291-8 Get rights and content

Abstract

We have previously shown that coupling bath application of dopamine with 50 Hz tetani induces long-term depression in rat prefrontal slices [Neuroscience 85 (1998) 669]. Here, we report a reliable protocol for inducing long-term potentiation in the same preparation. Long-term potentiation was induced by the same dopamine–tetani coupling protocol when the coupling was preceded (∼30 min) by a single bath application of dopamine. We suggest that metaplastic processes triggered by the first application of dopamine might underlie the LTP induction.

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Rapid communicationLong-term potentiation in rat prefrontal slices facilitated by phased application of dopamine

Abstract

Neuroscience

Neurosci. Lett.

Neuroscience

Medial frontal cortex mediates perceptual attentional set shifting in the rat

J. Neurosci.

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Long-term potentiation in rat prefrontal slices facilitated by phased application of dopamine