Axonal regeneration and formation of synapses proximal to the site of lesion following hemisection of the rat spinal cord
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Cited by (104)
Plasticity of thoracic interneurones rostral to a lateral spinal cord lesion
2020, Experimental NeurologyCitation Excerpt :Consistent with this, a marked increase in dendritic spine density on (indirectly identified) adult lumbar motoneurones has been shown following a mid-thoracic spinal cord transection (Cummings and Stelzner, 1988) or contusion (Bandaru et al., 2015), accompanied by a degree of hyperreflexia (Bandaru et al., 2015). The increased occurrence of spines in our data could suggest, similarly, an increased excitation of the interneurons following spinal cord injury, and is consistent with them being a target of sprouting from axotomised descending fibres (Bernstein and Bernstein, 1971; Ford et al., 2000; Ford et al., 2016). However, the degree of increased excitation must depend on the relative synaptic occupation for the other areas of new dendritic membrane within the overall dendritic reorganisation that appears to have taken place.
Multiple sclerosis - candidate mechanisms underlying CNS atrophy
2010, Trends in NeurosciencesCitation Excerpt :This correlates closely with studies in humans where, even years after spinal cord lesion, patients with functionally complete spinal cord injuries displayed normal numbers of axons in the corticospinal tract above the lesion site [103]. Moreover, the finding that lesioned corticospinal axons are able to sprout above the lesion site and form new synaptic contacts, strongly argues against significant retrograde degeneration of lesioned neurons or of their axons above the lesion site [89,104,105]. The presence of axonal lesions in MS patients might indicate that the parent neuron has a similar dying-back mechanism as has been shown for axonal lesions in peripheral nervous system (PNS) disorders.
Experimental strategies to promote axonal regeneration after traumatic central nervous system injury
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Supported by NIH grant NS 06164 (HEW).