Elsevier

Life Sciences

Volume 70, Issue 3, 7 December 2001, Pages 349-356
Life Sciences

Original articles
GABAB receptor agonist baclofen attenuates the development and expression of d-methamphetamine-induced place preference in rats

https://doi.org/10.1016/S0024-3205(01)01397-2Get rights and content

Abstract

The present study investigated the effect of systemic administration of the GABAB receptor agonist, baclofen, on the development and expression of d-methamphetamine (d-MA)-induced place preference in male Wistar rats. Using a biased and 8-day schedule of conditioning, it was found that administration of d-MA (0.5 mg/kg, IP) produced significant place preference. The administration of baclofen (2.5 and 5.0 mg/kg, IP) 30 min prior to the exposure to d-MA attenuated the development of d-MA-induced place preference (p<0.05). In addition, when it was acutely administered 30 min prior to the testing session of an already established d-MA place preference, baclofen (1.25–5.0 mg/kg, IP) attenuated the expression of this conditioned response in a dose-dependent manner. These results showed that baclofen suppressed the rewarding effect produced by d-MA and may be potentially effective in the treatment of methamphetamine dependence and craving.

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