Human blood-brain barrier insulin-like growth factor receptor☆,☆☆
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Insulin and the blood–brain barrier
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2022, Journal of Controlled ReleaseCitation Excerpt :On the other hand, the movement of solutes down the concentration gradient is mediated by solute transporters, such as glucose, amino acids, and fatty acids transporters. Several receptors as the transferrin receptor (TfR) [14] or the insulin-like growth factor receptor (IGFR) [15] are involved in receptor-mediated vesicular transport through the BBB. In some regions, such as the pineal gland, or the median eminence of the hypothalamus, the capillaries are fenestrated and allow direct communication between the blood and the brain.
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Supported by the Juvenile Diabetes Foundation, NIH grants RO1-AM28229 and RCDA AM-01275, and the US Army Medical Research and Development Command under Contract No. DAMD17-87-C-7137. Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the US Army.
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Presented at the Western Section American Federation of Clinical Research, Carmel, CA in February 1987 and at the American Society of Clinical Investigation, San Diego in May 1987.