Elsevier

Neuropharmacology

Volume 38, Issue 12, December 1999, Pages 1917-1920
Neuropharmacology

Rapid communication
Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome

https://doi.org/10.1016/S0028-3908(99)00083-0Get rights and content

Abstract

Long-term potentiation (LTP) and depression (LTD) were investigated in hippocampus of a genetic model of Down syndrome, the segmental trisomy (Ts65Dn) mouse. Field excitatory postsynaptic potentials were recorded from hippocampal slices and LTP and LTD evoked sequentially. LTP decreased whereas LTD increased significantly in Ts65Dn compared with control hippocampus.

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Acknowledgements

NIH Grants AG 08938 and HD 31498. We thank D. Matthews (NIH, NICHD) for assistance with the care of the segmental trisomy 16 mice and A. Finney for her help with karyotyping. We also thank Drs. Crnic, Krueger, Yarowski and Florez for discussions during Neuroscience Meetings. Finally, we thank Z. Bashir (University of Bristol, UK) for his critical reading of the manuscript and comments.

References (12)

  • W.W. Anderson et al.

    A data acquisition program for on-line analysis of long-term potentiation and long-term depression

    Society for Neuroscience Abstracts

    (1997)
  • Z.I. Bashir et al.

    An investigation of depotentiation of long-term potentiation in the CA1 region of the hippocampus

    Experimental Brain Research

    (1994)
  • S.M. Dudek et al.

    Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus

    Journal of Neuroscience

    (1993)
  • C.J. Epstein et al.

    Models for Down syndrome: chromosome 21-specific genes in mice

    Progess in Clinical Biological Research

    (1990)
  • D.M. Holtzman et al.

    Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

    Proceedings of the National Academy of Science USA

    (1996)
  • P.T. Huerta et al.

    Bidirectional synaptic plasticity induced by a single burst during cholinergic theta oscillation in CA1 in vitro

    Neuron

    (1995)
There are more references available in the full text version of this article.

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    LTP and LTD in striatal spiny neurons are unaffected, but LTP is decreased in striatal cholinergic interneurons (Di Filippo et al., 2010). Extracellular recordings of field EPSPs report weaker LTP but stronger LTD at excitatory synapses on CA1 neurons, due to enhanced GABAergic transmission (Andrade-Talavera et al., 2015; Belichenko et al., 2007; Chakrabarti et al., 2010; Costa and Grybko, 2005; Das et al., 2013; Deidda et al., 2015; Kaur et al., 2014; Mitra et al., 2012; Olson et al., 2007; Pereira et al., 2009; Siarey et al., 1999; Siarey et al., 1997; Siarey et al., 2005; Yu et al., 2010a; Yu et al., 2010b; Zhang et al., 2014), which may include an increase in excitatory, as well as inhibitory, GABAergic signalling mediated by GABAA or GABAB receptors (Contestabile et al., 2017; Deidda et al., 2015). Extracellular recordings of field EPSPs also report impaired LTP in synapses of the dentate gyrus (DG) and perirhinal cortex, due to enhanced GABAergic transmission (Belichenko et al., 2009; Belichenko et al., 2015; Contestabile et al., 2013; Fernandez et al., 2007; Kleschevnikov et al., 2012; Kleschevnikov et al., 2004; Morice et al., 2008; O'Doherty et al., 2005; Roncace et al., 2017).

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