Rapid communicationIncreased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
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Acknowledgements
NIH Grants AG 08938 and HD 31498. We thank D. Matthews (NIH, NICHD) for assistance with the care of the segmental trisomy 16 mice and A. Finney for her help with karyotyping. We also thank Drs. Crnic, Krueger, Yarowski and Florez for discussions during Neuroscience Meetings. Finally, we thank Z. Bashir (University of Bristol, UK) for his critical reading of the manuscript and comments.
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2020, iScienceCitation Excerpt :It should be noted that the inability to induce LTP/LTD in the DS neuronal culture may also be associated with reduced synaptic activity (Weick et al., 2013). Nevertheless, our observation in DS patient iPSC-derived neuronal network is very similar to the deficit or even complete lack of LTP reported in hippocampal CA1 synapses of adult Ts65Dn mice, a model for DS (Costa and Grybko, 2005; Kleschevnikov et al., 2004; Siarey et al., 1997, 1999). Since our model is based on precise control of synaptic transmission by light and intracellular recording, it offers a new way to assess human neural plasticity at the single-synapse level when combined with engineering tools.
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2018, Neurobiology of DiseaseCitation Excerpt :LTP and LTD in striatal spiny neurons are unaffected, but LTP is decreased in striatal cholinergic interneurons (Di Filippo et al., 2010). Extracellular recordings of field EPSPs report weaker LTP but stronger LTD at excitatory synapses on CA1 neurons, due to enhanced GABAergic transmission (Andrade-Talavera et al., 2015; Belichenko et al., 2007; Chakrabarti et al., 2010; Costa and Grybko, 2005; Das et al., 2013; Deidda et al., 2015; Kaur et al., 2014; Mitra et al., 2012; Olson et al., 2007; Pereira et al., 2009; Siarey et al., 1999; Siarey et al., 1997; Siarey et al., 2005; Yu et al., 2010a; Yu et al., 2010b; Zhang et al., 2014), which may include an increase in excitatory, as well as inhibitory, GABAergic signalling mediated by GABAA or GABAB receptors (Contestabile et al., 2017; Deidda et al., 2015). Extracellular recordings of field EPSPs also report impaired LTP in synapses of the dentate gyrus (DG) and perirhinal cortex, due to enhanced GABAergic transmission (Belichenko et al., 2009; Belichenko et al., 2015; Contestabile et al., 2013; Fernandez et al., 2007; Kleschevnikov et al., 2012; Kleschevnikov et al., 2004; Morice et al., 2008; O'Doherty et al., 2005; Roncace et al., 2017).