Elsevier

Neuroscience Letters

Volume 287, Issue 1, 16 June 2000, Pages 41-44
Neuroscience Letters

Effect of noradrenergic denervation of the amygdala upon recovery after sleep deprivation in the rat

https://doi.org/10.1016/S0304-3940(00)01106-XGet rights and content

Abstract

We previously showed that the noradrenergic locus coeruleus (NA-LC) was involved in the regulatory mechanisms of the paradoxical sleep rebound following a 10 h sleep deprivation by using a systemic injection of a specific neurotoxin, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4). Given that rebound mechanisms are mainly located in the forebrain, we planned to study the role of the forebrain structures receiving LC afferences. In this study we evaluated the involvement of noradrenergic afferences to the central nucleus of the amygdala in the sleep rebound by DSP-4 microinjections into the central nucleus of the rat amygdala. The results showed that during the first recovery day, the paradoxical sleep rebound is lower in DSP-4 treated rats (−67.28%). These findings indicate that the amygdala, through its NA afferents, contributes to the sleep rebound mechanisms.

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Acknowledgements

The authors would like to thank Dr Yves Charnay for his kind donation of rat DBH antibodies, Lucienne Léger for her helpful advice and Catherine Limoge for English revision of the manuscript. This work was supported by grants from the Fondation pour la Recherche Médicale (FRM) and from the INSERM (U480).

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