Anti-prion antibodies for prophylaxis following prion exposure in mice
Section snippets
Acknowledgements
This work was supported by the Alzheimer’s Association and NIH grants: AG17617, AG20245 and AG20197 and AR02594.
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Cited by (100)
Therapeutic implications of prion diseases
2021, Biosafety and HealthRecombinant prion protein vaccination of transgenic elk PrP mice and reindeer overcomes self-tolerance and protects mice against chronic wasting disease
2018, Journal of Biological ChemistryCitation Excerpt :There are no preventive or therapeutic measures available against CWD, nor for other prion diseases such as Creutzfeldt-Jakob disease in humans, scrapie in sheep, and bovine spongiform encephalopathy in cattle. The concept of active and passive immunization has already been introduced for prion disease, and reduced prion propagation in vitro and in vivo, and it prolonged the incubation period in murine-adapted scrapie prion models after immunization (21–26). Vaccination in prion disease would be useful to prevent peripheral infection before prions reach the brain, as the vast majority of antibodies cannot cross the blood–brain barrier (25–27).
Vaccination strategies
2018, Handbook of Clinical NeurologyEthics in prion disease
2013, Progress in NeurobiologyExosome release from infected dendritic cells: A clue for a fast spread of prions in the periphery?
2013, Journal of InfectionCitation Excerpt :In fact, passive immunization of mice with anti-PrP antibodies recently confirmed that the prion load in lymphatic tissue was greatly reduced and scrapie incubation times significantly prolonged.172–175