Proteolysis of highly polysialylated NCAM by the tissue plasminogen activator-plasmin system in rats
Section snippets
Acknowledgements
We thank Dr. Tatsunori Seki of the Juntendo University School of Medicine for the gift of the anti-rat NCAM-H antibody.
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A role of PSA-NCAM in the survival of retinal ganglion cells (RGCs) after kainic acid damage
2019, NeuroToxicologyCitation Excerpt :It has been shown that the ADAMs family of metalloproteinases are also involved in PSA-NCAM/NCAM degradation (Kalus et al., 2006). Furthermore, PSA-NCAM is degraded in the neonatal brain by plasmin, known as endopeptidase, and inhibitors of plasminogen activators (PAs) decrease PSA-NCAM shedding (Endo et al., 1998). Several studies showed that KA-induced hyperstimulation of non-NMDA receptors in the retina upregulated PAs and active plasmin, which was associated with RGC death and inhibition of PAs attenuated RGCs damage (Mali et al., 2005).
Urokinase and urokinase receptor participate in regulation of neuronal migration, axon growth and branching
2016, European Journal of Cell BiologyPolysialic acid enters the cell nucleus attached to a fragment of the neural cell adhesion molecule NCAM to regulate the circadian rhythm in mouse brain
2016, Molecular and Cellular NeuroscienceCitation Excerpt :Because of PSA's ability to modify the functions of NCAM at the cell surface, little interest had been focused on PSA in other cellular compartments. Since proteolytic NCAM fragments comprising the extracellular parts influence cell interactions at the cell surface, the functions of these fragments, which are generated by different metalloproteases and serine proteases, have received increasing attention (Endo et al., 1998, 1999; Hubschmann et al., 2005; Pillai-Nair et al., 2005; Kalus et al., 2006; Dean and Overall, 2007; Brennaman et al., 2011; Shichi et al., 2011). However, little is known about the functions of NCAM fragments containing the intracellular domain, the transmembrane portion and part of the extracellular domain carrying PSA.
Serum markers in small cell lung cancer: Opportunities for improvement
2013, Biochimica et Biophysica Acta - Reviews on CancerStress-induced spine loss in the medial amygdala is mediated by tissue-plasminogen activator
2007, NeuroscienceCitation Excerpt :As a protease, tPA has narrow substrate specificity, but its effects can be amplified by activation of a zymogen plasminogen to a broad-spectrum protease plasmin. Plasmin-mediated proteolysis can render the environment more permissive for structural plasticity, by acting upon a wide variety of substrates, including extracellular matrix proteins (Chen and Strickland, 1997), growth factors and neurotrophins (Mars et al., 1993; Pang et al., 2004), membrane receptors (Matys and Strickland, 2003; Pawlak et al., 2005), and cell adhesion molecules (Endo et al., 1998). Recent studies suggest that extracellular matrix degradation by plasmin is critical for dendritic spine plasticity in other brain regions (Mataga et al., 2004; Oray et al., 2004).