Stress-induced changes of norepinephrine uptake sites in the locus coeruleus of C57BL/6J and DBA/2J mice: a quantitative autoradiographic study using [3H]-tomoxetine
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Acknowledgements
This work was in part supported by PHS grant NS-25087. Special thanks go to Dr. Guoming Wang and Ms. Jaime Guntz for their technical assistance, and Mr. Kuolung Hu for his statistical analysis on the behavioral and neurochemical paradigms.
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Morphological and Functional Changes of Locus Coeruleus in Patients with Primary Open-Angle Glaucoma and Animal Models
2018, NeuroscienceCitation Excerpt :However, the mechanism of cell apoptosis in the LC still remains unknown. There were studies already reported that in DBA 2/J mice, alterations in the norepinephrine uptake in the LC may associate with susceptibility to stress-induced behavioral depression (Shanks et al., 1991; Hwang et al., 1999). Here, we offered another possibility that LC alterations in DBA 2/J might also be associated with elevated IOP.
Reversal of age-associated cognitive deficits is accompanied by increased plasticity-related gene expression after chronic antidepressant administration in middle-aged mice
2015, Pharmacology Biochemistry and BehaviorCitation Excerpt :Firstly, it is sensitive to and predictive of the success of antidepressants (Cooper et al., 1980; Dulawa et al., 2004; Harkin et al., 1999; Karpa et al., 2002; Kusmider et al., 2006; Porsolt et al., 1978; Willner, 1995). Secondly, many of the circumstances thought to promote depression in humans also induce behavioral ‘despair’ in the forced swim test (Boccia et al., 2007; Bulduk and Canbeyli, 2004; Friedman et al., 2006; Hoshaw et al., 2006; Hwang et al., 1999; Lee et al., 2007; Pare, 1992; Ruedi-Bettschen et al., 2006; Wann et al., 2007; Willner, 1995; Willner and Mitchell, 2002). Lastly, the physiological responses, the brain regions and underlying mechanisms regulating immobility in the forced swim test behavior are similar to findings in depressed humans (Arletti and Bertolini, 1987; Flugy et al., 1992; Gil et al., 1992; Hattori et al., 2007; Hwang et al., 1999; Jesberger and Richardson, 1985; Kostowski, 1985; Kostowski et al., 1984; McKinney, 1984; Overstreet, 1986; Pare, 1989, 1992; Porsolt, 1979; Porsolt et al., 1979; White et al., 2007; Willner, 1984, 1995) and to other animal assays of depression (Gil et al., 1992; Kostowski et al., 1992; Pare, 1994; Willner, 1995).
Beneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety- and depression-like behaviors
2013, Behavioural Brain ResearchCitation Excerpt :Brown et al. [34] provided evidence that patients with chronic glucocorticoid therapy had decreases in hippocampal volume and declarative memory performance with an increase in depressive symptom. At the cellular level, norepinephrine uptake sites as determined by [3H]-tomoxetine autoradiography was markedly increased in the locus coeruleus of restraint stressed mice [35], consistent with a recent report that showed the corticosterone-induced increases in the protein expression and activity of norepinephrine transporter (NET) in human neuroblastoma cells [36]. In mice susceptible to anhedonia, the mRNA levels of serotonin reuptake transporter (SERT) was also increased in the prefrontal cortex [37].
Chronic social defeat up-regulates expression of norepinephrine transporter in rat brains
2012, Neurochemistry InternationalCitation Excerpt :These findings suggest that depressive behavior in stressed animals requires functional NET and that abnormal NET expression and function could contribute to depressive symptoms (Haenisch et al., 2009; Haller et al., 2002). Likewise, the involvement of NET in stress has been reported previously (Hwang et al., 1999; Rusnak et al., 2001; Zafar et al., 1997). However, effects of stress on NET expression are inconsistent and stressor-dependent.
The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice
2007, PsychoneuroendocrinologyCitation Excerpt :Prior exposure to the NE had only a minor influence on stress coping behavior as it mainly decreased swimming behavior in both strains. It should be noted that there are discrepancies with previous reports that (un-stressed) C57BL/6 mice are more immobile in the FST than DBA/2 mice (Hwang et al., 1999; Ventura et al., 2002). Such differences in the outcome of behavioral studies can be partly explained by the influence of laboratory environment and experimental procedure (Chesler et al., 2002; Crabbe et al., 1999) and, importantly, by the use of different strain subtypes (Siegmund et al., 2005; Wotjak, 2003).
Antidepressant-like effects in various mice strains in the tail suspension test
2003, Behavioural Brain Research