Correspondence
References (0)
Cited by (99)
Reduction of glutamate neurotoxicity: A novel therapeutic approach for Niemann-Pick disease, type C1
2021, Molecular Genetics and MetabolismCitation Excerpt :In the cerebellum, SLC1A3 is expressed uniformly by glial cells including both Bergmann and radial glia which are closely associated with the soma of Purkinje neurons [14]. SLC1A6 is expressed by Purkinje neurons, with higher SLC1A6 expression in aldolase C positive Purkinje neurons [12,15]. Glutamate hyperstimulation leads to increase calcium influx, mitochondrial dysfunction and unregulated activation of degradative enzymes that ultimately results in cell death [16,17].
Parvalbumin subtypes of cerebellar Purkinje cells contribute to differential intrinsic firing properties
2021, Molecular and Cellular NeuroscienceCitation Excerpt :Heterogeneous populations of PCs in parasagittally-oriented stripes were described by Gravel et al. (1987) and are perhaps best exemplified by labeling of aldolase C (originally zebrin II), which has served as a useful landmark to compare other markers that appear complementary (Brochu et al., 1990; Fujita et al., 2014). As aldolase C positive and negative stripes are differentially contacted topographically by cells projecting from the inferior olive and have been shown to have differences in expression of the glutamate transporter EAAT4 (Nagao et al., 1997; Dehnes et al., 1998; Hawkes, 2014), it stood to reason that these groups of PCs would have functional physiological differences. Only recently have differences in physiological properties between PC stripes been reported, notably that aldolase C negative PCs display higher simple spike firing frequencies than positive cells (Xiao et al., 2014; Zhou et al., 2014; Nguyen-Minh et al., 2019).
Cerebellar patterning
2020, Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, Second EditionInsights into cerebellar development and connectivity
2019, Neuroscience LettersAstroglial glutamate transporters coordinate excitatory signaling and brain energetics
2016, Neurochemistry InternationalThe SLC1 high-affinity glutamate and neutral amino acid transporter family
2013, Molecular Aspects of Medicine