Original contributionAnisotropic water diffusion in white and gray matter of the neonatal piglet brain before and after transient hypoxia-ischaemia
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Microstructure abnormity in the optic nerve of type 1 diabetic rats revealed by diffusion tensor imaging study
2020, Magnetic Resonance ImagingRecent advances in preclinical and clinical multimodal MR in the newborn brain
2018, Journal of Magnetic ResonanceCitation Excerpt :The identification of visible focal inflammatory injury in the first weeks of life confirms the need to provide early neuroprotection before established white matter atrophy with corpus callosum thinning, ventricular dilation and dysmaturation all known to worsen neurodevelopmental outcome [14]. Spectroscopy in the hypoxic-ischemic piglet model: Piglets, exposed to a hypoxic-ischemic injury to reproduce birth asphyxia, develop imaging and spectroscopic changes identical to what is seen in term newborns infants with a reduction of ADC, changes in phosphorus spectroscopy showing secondary energy failure with a significant reduction of the high energy metabolite phosphocreatine with a concomitant rise in inorganic phosphate [15]. 31PMRS used in this model, showed the protection obtained by hypothermia against secondary energy failure [16].
Using diffusion anisotropy to study cerebral cortical gray matter development
2018, Journal of Magnetic ResonanceSpatial mapping of structural and connectional imaging data for the developing human brain with diffusion tensor imaging
2015, MethodsCitation Excerpt :The cortical FA is low around birth at 37 pcw and remains low from 37 pcw to 32 years. In the fetal stage, FA values of the cortical plate are high [e.g. 13,48,53–63] due to the dominant organized radial glial scaffold in the cortex. The disruption of the columnar structures caused by loss of radial glia, synapse formation and increased dendritic density [e.g. 48,56,62] leads to a decrease in FA values.
Mapping somatosensory connectivity in adult mice using diffusion MRI tractography and super-resolution track density imaging
2014, NeuroImageCitation Excerpt :We found a higher signal intensity in the septal area of Layer IV barrel cortex, compared to the barrel hollows, using whole brain tracking (current study and (Kurniawan et al., 2014)) and thalamo-cortical targeted tracking. These findings would not result from connectivity between adjacent Layer IV barrels (Feldmeyer, 2012) and, although there is evidence to suggest a higher concentration of myelin within the septal area compared to barrel hollows (Barrera et al., 2012), myelin is not essential for anisotropic diffusion in nerve fibers, with evidence of minor amounts of anisotropy in rodent and piglet cortex (Hoehn-Berlage et al., 1999; Mori et al., 2001; Thornton et al., 1997). In fact, anisotropy from un-myelinated nerves in garfish (Beaulieu and Allen, 1994), rodent (Seo et al., 1999), zebrafish (Ullmann et al., 2013) and human fetal brain (Tucciarone et al., 2009) suggests that the radial alignment of microstructure including cell membranes is a sufficient barrier to diffusion to result in anisotropic diffusivity.