Neuron
Volume 25, Issue 2, February 2000, Pages 449-457
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Article
Interactions between Distinct GABAA Circuits in Hippocampus

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Abstract

Synchronous activity among synaptically connected interneurons is thought to organize temporal patterns such as gamma and theta rhythms in cortical circuits. Interactions between distinct interneuron circuits may underlie more complex patterns, such as nested rhythms. Here, we demonstrate such an interaction between two groups of CA1 interneurons, GABAA,slow and GABAA,fast cells, that may contribute to theta and gamma rhythms, respectively. Stratum lacunosum-moleculare (SL-M) stimuli that activate GABAA,slow inhibitory postsynaptic currents (IPSCs) in pyramidal cells simultaneously depress the rate and amplitude of spontaneous GABAA,fast IPSCs for several hundred milliseconds. This suppression has a similar pharmacological profile to GABAA,slow IPSCs, and SL-M stimuli elicit GABAA,slow IPSCs in interneurons. We conclude that GABAA,slow cells inhibit both pyramidal cells and GABAA,fast interneurons and postulate that this interaction contributes to nested theta/gamma rhythms in hippocampus.

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