Light-induced retinopathy in the albino rat in long-term studies: An immunohistochemical and quantitative approach
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Cited by (33)
Predicting toxicities in humans by nonclinical safety testing: an update with particular reference to anticancer compounds
2017, Drug Discovery TodayCitation Excerpt :During clinical trials, three out of 1108 patients reported events of reversible posterior leukoencephalopathy syndrome (RPLS). Retinal toxicity is a particular type of neural toxicity and needs to be distinguished in particular from the light-induced retinopathy of albino rodents [12]. Early retinal toxicity can manifest even in a 2-week study [13].
Best Practice in Toxicological Pathology
2016, A Comprehensive Guide to Toxicology in Nonclinical Drug DevelopmentBest Practice in Toxicological Pathology
2013, A Comprehensive Guide to Toxicology in Preclinical Drug DevelopmentAn antibody panel for immunohistochemical analysis of the retina in Davidson's-fixed, paraffin-embedded eyes of rats
2009, Experimental and Toxicologic PathologyWhat is it like to be a rat? Rat sensory perception and its implications for experimental design and rat welfare
2008, Applied Animal Behaviour ScienceSustained upregulation of glial fibrillary acidic protein in Müller cells in pigeon retina following disruption of the parasympathetic control of choroidal blood flow
2006, Experimental Eye ResearchCitation Excerpt :Our results with the AP-lesioned birds leave open the possibility that long-term impairment of pupil constriction could be harmful to the eye. The evidence that excess light injures the eye is consistent with this possibility (Noell et al., 1966; Marshall et al., 1972; Lanum, 1978; Shahinfar et al., 1991; Fite et al., 1993; Organisciak and Winkler, 1994; Perez and Perentes, 1994). Clinical studies in humans with diseases that impair pupil constriction are also consistent with this possibility, since such patients show declines in retinal contrast sensitivity and acuity (Laor and Korczyn, 1978; Gräf and Jungherr, 2002).