Mitogen-activated protein kinase cascades and regulation of gene expression

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Abstract

Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine specific, proline directed, protein kinases which are activated by a wide spectrum of extracellular stimuli. MAPK activation is achieved through kinase cascades, which include a MAPK kinase (MAPKK or MEK) and a MAPKK/MEK kinase (MAPKKK/MEKK). These cascades serve as information relays, connecting cell-surface receptors to specific transcription factors and other regulatory proteins, thus allowing extracellular signals to regulate the expression of specific genes. Genetic and biochemical analyses have revealed many tiers in the regulation of the activities of MAPKs, as well as different routes that lead to the activation of an individual MAPK. An emerging topic of great interest is the basis for specificity in the activation of individual MAPKs and their ability to recognize their substrates.

References (95)

  • E Leberer et al.

    The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signaling components

    EMBO J

    (1992)
  • ZS Zhao et al.

    Pheromone signalling in Saccharomyces cerevisiae requires the small GTP-binding protein CDC42p and its activator

    Mol Cell Biol

    (1995)
  • J Han et al.

    Endotoxin induces rapid protein tyrosine phosphorylation in 70Z/3 cells expressing CD14

    J Biol Chem

    (1993)
  • KY Choi et al.

    Ste5 tethers multiple protein kinase in the MAP kinase cascade required for mating in S. cerevisiae

    Cell

    (1994)
  • CS Hill et al.

    Transcriptional regulation by extracellular signals: mechanisms and specificity

    Cell

    (1995)
  • R Treisman

    The serum response element

    Trends Biochem Sci

    (1992)
  • M Sheng et al.

    CREB: a Ca2+-regulated transcription factor phosphorylated by calmodulin-dependent kinases

    Science

    (1991)
  • Z Arany et al.

    EIA-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

    Cell

    (1994)
  • S Gupta et al.

    Transcription factor ATF2 regulation by the JNK signal transduction pathway

    Science

    (1995)
  • P Young et al.

    Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level

    Agents Actions

    (1993)
  • AP Nair et al.

    Cyclosporin A inhibits growth of autocrine tumour cell lines by destabilizing interleukin-3 mRNA

    Nature

    (1994)
  • A Casillas et al.

    Stimulation of B-cells via the membrane immunoglobulin receptor or with phorbol myristate 13-acetate induces tyrosine phosphorylation and activation of a 42-kDa microtubule-associated protein-2 kinase

    J Biol Chem

    (1991)
  • J Alberola-Ila et al.

    Selective requirement for MAP kinase activation in thymocyte differentiation

    Nature

    (1995)
  • RH Schwartz

    Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

    Cell

    (1992)
  • R Segar et al.

    The MAPK signaling cascade

    FASEB J

    (1995)
  • BB Derijard et al.

    JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

    Cell

    (1994)
  • JM Kyriakis et al.

    The stress-activated protein kinase subfamily of c-Jun kinases

    Nature

    (1994)
  • T Kallunki et al.

    JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation

    Genes Dev

    (1994)
  • J Han et al.

    A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

    Science

    (1994)
  • JC Lee et al.

    A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

    Nature

    (1994)
  • NW Freshney et al.

    Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27

    Cell

    (1995)
  • J Rouse et al.

    A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

    Cell

    (1995)
  • T Deng et al.

    c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK

    Nature

    (1994)
  • GC Zhou et al.

    Components of a new human protein kinase signal transduction pathway

    J Biol Chem

    (1995)
  • M Karin

    The regulation of AP-1 activity by mitogen-activated protein kinase

    J Biol Chem

    (1995)
  • TW Sturgil et al.

    Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

    Nature

    (1988)
  • B Su et al.

    JNK is involved in signal integration during costimulation of T lymphocytes

    Cell

    (1994)
  • CM Crews et al.

    The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product

    Science

    (1992)
  • CF Zheng et al.

    Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

    J Biol Chem

    (1993)
  • SA Moodie et al.

    Complexes of Ras. FTP with raf-1 and mitogen-activated protein kinase kinase

    Science

    (1993)
  • JM Kyriakis et al.

    Raf-1 activates MAP kinase-kinase

    Nature

    (1992)
  • CA Lange-Carter et al.

    A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

    Science

    (1993)
  • SE Egan et al.

    The pathway to signal achievement

    Nature

    (1993)
  • BJ Stevenson et al.

    Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein

    Genes Dev

    (1992)
  • A Minden et al.

    Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-I and MEKK

    Science

    (1994)
  • S Xu et al.

    MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

    Proc Natl Acad Sci USA

    (1995)
  • T Maeda et al.

    Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor

    Science

    (1995)
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