Regulation of gene expression by nucleosomes
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Cited by (59)
Substituent effect of benzyl moiety in nitroquinoxaline small molecules upon DNA binding: Cumulative destacking of DNA nucleobases leading to histone eviction
2022, European Journal of Medicinal ChemistryCitation Excerpt :Chromatin is a well-regulated complex core of histone proteins, DNA, and other nucleoproteins [8–10]. Inside a cell, DNA exists as a finely regulated complex structure (nucleosome), which is an integral part of the chromatin [11–13]. The structural integrity of chromatin or nucleosome is the foremost factor for the proper regulation of cellular functions such as replication, transcription, etc., and cell survival [1].
Nucleosome positioning: Bringing order to the eukaryotic genome
2012, Trends in Cell BiologyCitation Excerpt :Third, nucleosomes can directly regulate the access of trans-acting factors to functional elements on chromosomes because of how they are positioned relative to these elements. Studies stretching back more than two decades have shaped the idea that nucleosomes, by impeding access of the transcription machinery to genomic DNA, are a general inhibitory influence on transcription [6–10]. A cornerstone of this idea is that a sequence occupied by a nucleosome is refractory to binding by other factors.
Nucleosome Positioning Determinants
2007, Journal of Molecular BiologyBoth DNA and histone fold sequences contribute to archaeal nucleosome stability
2002, Journal of Biological ChemistrySsn6-Tup1 Regulates RNR3 by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream Repression Sequence
2001, Journal of Biological ChemistryCitation Excerpt :Restriction endonuclease sites located within a nucleosome are more resistant to digestion compared with sites located in nucleosome-free regions or in regions containing DNA-binding proteins (54, 55). This method has been used extensively to quantify the extent of nucleosome remodeling at the PHO5 promoter (4,55). The accessibility of two restriction endonuclease sites located within the RNR3 promoter was tested.
Chromatin structure at the 3′-boundary of the human β-globin locus control region hypersensitive site-2
2001, International Journal of Biochemistry and Cell Biology