Original ArticleAssociation Between Response Inhibition and Working Memory in Adult ADHD: A Link to Right Frontal Cortex Pathology?
Section snippets
Subjects
Twenty subjects with a DSM-IV diagnosis of ADHD were recruited from a clinic that specializes in the assessment of suspected adult ADHD. Data from ADHD subjects were collected as part of the placebo arm of a pharmacologic challenge study (Turner et al. 2004). Demographic characteristics are described in Table 1. Informant ratings (usually from a parent) were used to assess ADHD symptoms during childhood, and ratings by the patient and an informant were used to assess symptoms experienced during
Adult ADHD Group Versus Healthy Controls
Neuropsychological performance in the adult ADHD and healthy control groups is shown in Table 3. On the SWM task, the adult ADHD group made more BSE than did controls [t(34) = 1.98; p = .028, one-tailed]. When level of difficulty (four-, six-, and eight-move problems) was entered as a within-subjects variable in a mixed-model ANOVA, there was a significant group-by-difficulty interaction [F(1.5, 49.3) = 4.71, p = .022, Greenhouse-Geisser corrected] and main effect of difficulty level [F(1.5,
Discussion
In adult subjects with ADHD, response inhibition, as indexed by SSRT, was correlated significantly with BSE on a self-ordered SWM task. These two constructs, which are independently reliable deficits in ADHD groups (Lijffijt et al 2005, Martinussen et al 2005), appear to be associated in the adult variant of the disorder. Intriguingly, the same association between response inhibition and working memory search errors also was identified in a group of neurosurgical patients with unilateral
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