Archival ReportProgressive Deformation of Deep Brain Nuclei and Hippocampal-Amygdala Formation in Schizophrenia
Section snippets
Participants
The subjects in the present study were selected from groups of schizophrenia (n = 139, male/female = 90/49, age = 35.0 ± 13.0 years) and healthy comparison subjects (n = 136, male/female = 73/63, age = 33.3 ± 14.1 years) that were enrolled into an ongoing study of brain structure and schizophrenia. From these subjects, 56 schizophrenia and 62 healthy comparison subjects returned for follow-up and were included in the present study. All individuals gave written informed consent for participation
Participants
Compared with the subjects who returned for follow-up, subjects who did not return were younger (30.8 ± 13.5 years, p = .027) and had a shorter duration of illness (10.5 ± 9.9 years, p = .013) at baseline, but they did not differ in psychopathology as assessed using the total scores from SAPS (p = .23) and SANS (p = .65).
For the schizophrenia subjects, a repeated-measures general linear model with time as a repeated factor on clinical symptom domain scores showed no time effect for positive
Discussion
In this study, we found that progressive change in the deep brain nuclei and hippocampal-amygdala formation in subjects with schizophrenia was of modest magnitude and extent: As predicted, the structure of the thalamus, caudate, hippocampus, and nucleus accumbens showed disease-specific progressive (shape) changes, whereas the globus pallidus did not. However, putamen and amygdala showed progressive changes that were similar in the groups of schizophrenia and comparison subjects. When adjusted
References (68)
Emerging principles of altered neural circuitry in schizophrenia
Brain Res Brain Res Rev
(2000)- et al.
Structural analysis of the basal ganglia in schizophrenia
Schizophr Res
(2007) - et al.
Neocortical gray matter volume in first-episode schizophrenia and first-episode affective psychosis: A cross-sectional and longitudinal MRI study
Biol Psychiatry
(2007) - et al.
Longitudinal study of brain morphology in first episode schizophrenia
Biol Psychiatry
(2001) - et al.
NMDA receptor hypofunction model of schizophrenia
J Psychiatr Res
(1999) - et al.
Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat
Brain Res Dev Brain Res
(2002) - et al.
The Continuous Performance Test, identical pairs version (CPT-IP): INew findings about sustained attention in normal families
Psychiatry Res
(1988) - et al.
A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: Reliability and validation against manual measurement of total intracranial volume
Neuroimage
(2004) - et al.
Computational anatomy and neuropsychiatric disease: Probabilistic assessment of variation and statistical inference of group difference, hemispheric asymmetry, and time-dependent change
Neuroimage
(2004) - et al.
Validity of large-deformation high dimensional brain mapping of the basal ganglia in adults with Tourette syndrome
Psychiatry Res
(2007)