Brief ReportTotal Brain Volume and Corpus Callosum Size in Medication-Naïve Adolescents and Young Adults with Autism Spectrum Disorder
Section snippets
Methods and Materials
Thirteen male and 2 female subjects with autism spectrum disorder (mean age 17.5 years, SD 3.5 years) and 13 male and 2 female age-matched control subjects (mean age 18.6 years, SD 1.1 years) with IQ > 70 were assessed. After complete description of the study, informed consent was obtained from all participants and/or their parents. The study design was approved by the local ethical committee (Ethikkommission der Ärztekammer des Saarlandes). Detailed inclusion and exclusion criteria, methods to
Results
Descriptive data of the sample are shown in Table 1. With adjustment for IQ and interaction of IQ*status, TBV, GM, and WM were larger in ASD than in control individuals (Table 2), predominantly due to individuals with low IQ (Table 1 in Supplement 2). The interaction effect of IQ*status on TBV, GM, and WM indicates contrasting correlations of IQ with TBV, GM, and WM in case and control individuals. While IQ was not associated with TBV, GM, or WM in ASD subjects, control individuals showed
Discussion
In this study, TBV, GM, WM, and CC area were compared between 15 adolescents and young adults with ASD and 15 healthy control subjects, matched for gender and age. Our findings corroborate previous reports of an enlargement of TBV in adolescents and young adults with ASD (1), especially in individuals with average and below average IQ (70–110). The current analyses suggest that increases in TBV are due to increases in both GM and WM. Given that subjects in our study were medication-naïve, the
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