Archival ReportAntidepressant-Like Effects of Medial Prefrontal Cortex Deep Brain Stimulation in Rats
Section snippets
Methods and Materials
All protocols were approved by the Animal Care committee of the Centre for Addiction and Mental Health.
Outcome of vmPFC DBS in the FST
Animals treated with vmPFC DBS (n = 13) showed a 45% decrease in immobility scores compared with control animals (n = 12; p = .004; Figure 1B). A similar antidepressant-like response was not observed after striatal stimulation (n = 6; Figure 1C), suggesting that the effects of DBS had some target specificity. As a positive control, imipramine-treated rats (n = 8) had a 55% reduction in immobility scores (p = .002; Figure 1D), a magnitude of response similar to that in the DBS group.
To rule out
Discussion
We found that vmPFC DBS induced a clear antidepressant-like response in the FST, a well-established paradigm to assess antidepressant activity in rodents (16, 17, 18, 19, 20). In addition to different classes of medications, interventions such as electroconvulsive therapy and vagus nerve stimulation have all shown antidepressant-like effects in this model (16, 17, 18, 19, 20, 21, 24, 34). While the predictive validity of the FST is strong, a common criticism to its face validity refers to the
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