Archival Report5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress
Section snippets
Rats
Adult (60–70 days old and weighing 275–350 g at the time of testing) and juvenile (28–32 days old and weighing 90–100 g at the time of testing) male Sprague-Dawley (Harlan, Indianapolis, Indiana) rats were used in all experiments. Rats were housed with free access to food and water in groups of two for microinjection experiments, in groups of four when drugs were administered intraperitoneally (IP), and in single cages for the microdialysis experiment. The vivarium maintained a 12-hour
Extracellular BLA 5-HT During and Following Social Exploration
Importantly, all rats in the ES group learned to escape the tail shock, quickly reached the maximum response criterion, and maintained escape behavior as previously reported (14). Only rats with dialysis probes at least 50% within the BLA were included (Figure 1); the resulting groups had NS = 6–7. Prior stress did not alter basal 5-HT, means (SEM): ES = .272 (.03), IS = .267 (.05), HC = .274 (.04) pg/20 μL. Extracellular 5-HT was converted to percentage of baseline by dividing each sample by
Discussion
Here we explored the role of the DRN, 5-HT, and BLA 5-HT2C receptors in uncontrollable stress-induced anxiety-like behavior in the JSE test. Consistent with our prior work and that of others, exposure to an uncontrollable stressor (IS) reduced the rat's tendency to investigate a juvenile conspecific (12, 13, 37), whereas equal controllable stress did not (12, 36). The hypothesis has been that IS produces an intense activation of DRN 5-HT neurons, leading to sensitization of these neurons via
References (51)
Early predictors of posttraumatic stress disorder
Biol Psychiatry
(2003)- et al.
Stressor controllability and learned helplessness: The roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor
Neurosci Biobehav Rev
(2005) - et al.
Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear
Neuroscience
(2007) - et al.
The role of prior stressor controllability and the dorsal raphe nucleus in sucrose preference and social exploration
Behav Brain Res
(2008) - et al.
Stressor controllability, social interaction, and benzodiazepine systems
Pharmacol Biochem Behav
(1993) - et al.
Acute selective serotonin reuptake inhibitors increase conditioned fear expression: Blockade with a 5-HT(2C) receptor antagonist
Biol Psychiatry
(2007) - et al.
A review of 25 years of the Social Interaction Test
Eur J Pharmacol
(2003) - et al.
Activation of serotonin-immunoreactive cells in the dorsal raphe nucleus in rats exposed to an uncontrollable stressor
Brain Res
(1999) - et al.
Role of the bed nucleus of the stria terminalis versus the amygdala in fear, stress, and anxiety
Eur J Pharmacol
(2003) - et al.
Serotonin 2C receptors within the basolateral amygdala induce acute fear-like responses in an open-field environment
Brain Res
(2003)
Escapable and inescapable stress differentially alter extracellular levels of 5-HT in the basolateral amygdala of the rat
Brain Res
Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus
Neuropsychopharmacology
Stress-induced social avoidance: A new model of stress-induced anxiety?
Physiol Behav
Aggressive encounters alter the activation of serotonergic neurons and the expression of 5-HT1A mRNA in the hamster dorsal raphe nucleus
Neuroscience
Activation of 5-HT1A autoreceptors in the dorsal raphe nucleus reduces the behavioral consequences of social defeat
Psychoneuroendocrinology
Reduced serotonin-1A receptor binding in social anxiety disorder
Biol Psychiatry
The neurobiology and control of anxious states
Prog Neurobiol
Modulation of GABAA receptor function by G protein-coupled 5-HT2C receptors
Neuropharmacology
Posttraumatic stress disorder in the National Comorbidity Survey
Arch Gen Psychiatry
Pharmacotherapy for post-traumatic stress disorder: A comprehensive review
Expert Opin Pharmacother
Diagnostic and Statistical Manual of Mental Disorders
Treatment of acute stress disorder: A randomized controlled trial
Arch Gen Psychiatry
The psychobiology of depression and resilience to stress: Implications for prevention and treatment
Annu Rev Clin Psychol
Uncontrollability and unpredictability in post-traumatic stress disorder: An animal model
Psychol Bull
Role of fear in mediating shuttle escape learning deficit produced by inescapable shock
J Expert Psychol Anim Behav Process
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