Archival ReportVentral Striatum Reactivity to Reward and Recent Life Stress Interact to Predict Positive Affect
Section snippets
Participants
A total of 200 participants were included from the ongoing Duke Neurogenetics Study, which assesses a wide range of behavioral and biological traits among nonpatient, young adult, student volunteers. All participants provided informed consent in accordance with Duke University guidelines and were in good general health. Twenty-nine participants were excluded from analyses due to signal dropout in VS regions of interest (see below) and 1 participant did not have valid self-report data due to
Sample Demographics
There were no significant effects of gender or age on any self-report measure (Table 1). However, several trend-level effects emerged (Table 1). In addition, consistent with previous literature (36), men had higher right VS reactivity compared with women (p = .032). Finally, race/ethnicity had a significant effect on CES-D total and all CES-D subscales except interpersonal functioning (Table 2). To account for the potentially confounding effects of these demographic variables, all analyses were
Discussion
Consistent with theoretical predictions that robust responsiveness to reward may protect against the depressogenic effects of stress (12), we provide empirical evidence that recent life stress interacts with reward-related ventral striatum reactivity to predict self-reported state positive affect. Specifically, we show that recent life stress is associated with decreased PA only in individuals with relatively low VS reactivity. In those with relatively high VS reactivity, levels of PA did not
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