Archival ReportConnections of the Mouse Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by Brain-Derived Neurotrophic Factor☆,☆☆
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Methods and Materials
For additional details, see Supplemental Methods and Materials.
The Mouse OFC Innervates the Dorsal Striatum and Amygdala
We first compared projection patterns between the well-studied dorsolateral OFC/agranular insula (AI) and the adjacent ventrolateral OFC. Infusion of BDA into the ventrolateral OFC (Figure 1A) revealed innervation of both the dorsal striatum and the amygdala to be overwhelmingly ipsilateral. The central aspect of the dorsal striatum received heavy innervation broadly along the rostrocaudal axis (Figure 1B). By contrast, only light labeling was present in the ventral striatum. Fibers entered the
Discussion
Considerable evidence indicates that the OFC encodes salient information regarding desirable outcomes, such as external cues signaling reinforcement as well as the value of rewards (2). The OFC may also guide outcome-based decision making based on other reinforcement-related information, such as the likelihood that a given behavior will be reinforced, but to date, relatively few investigations into OFC function have focused on action-outcome associative learning and memory. We addressed this
Acknowledgments and Disclosures
This work was supported by Grant Nos. T32DA015040, P51OD011132, P30NS055077, DA034808, DA036737 (National Institutes of Health), Children’s Healthcare of Atlanta, Brain and Behavior Research Foundation Katherine Deschner Family Investigator award (SLG), and National Institute of Mental Health Biobehavioral Research Awards for Innovative New Scientists Grant No. MH101477 (SLG).
We thank Ms. Amanda Allen, Dr. R. Jude Samulski, and Mr. Zach Liang for their contributions and Ms. Lauren Shapiro, Dr.
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Ethanol modulation of cortico-basolateral amygdala circuits: Neurophysiology and behavior
2021, NeuropharmacologyCitation Excerpt :Pharmacological or DREADD-dependent inactivation of the lateral OFC does not appear to alter drug self-administration but rather disrupts relapse-like responding for both natural rewards (Hernandez et al., 2020) and abused drugs like ethanol (Arinze and Moorman, 2020; Hernandez et al., 2020), cocaine (Lasseter et al., 2014), and opiates (Reiner et al., 2020). Chemogenetic inhibition similarly reduces extinction memory expression following auditory fear conditioning/extinction training (Zimmermann et al., 2017). Oddly, pharmacological inactivation of the lateral OFC increases the expression of innate anxiety-like behavior (Kuniishi et al., 2017).
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We thank Ms. Amanda Allen and Mr. Zach Liang for their contributions and Ms. Lauren Shapiro, Dr. Geoffrey Schoenbaum, and Dr. Christopher Muly for guidance and valuable feedback.
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The authors report no biomedical financial interests or potential conflicts of interest.