Cell
Volume 136, Issue 6, 20 March 2009, Pages 990-992
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DISC1 Partners with GSK3β in Neurogenesis

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The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3β/β-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.

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