Cell
Volume 146, Issue 2, 22 July 2011, Pages 247-261
ArticleFMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Under an Elsevier user license
open archive
Graphical Abstract
Highlights
► Identification of a robust, reproducible, novel set of in vivo FMRP targets ► FMRP targets encode key pre- and postsynaptic proteins and autism candidate genes ► FMRP stalls ribosomes along the coding region of its mRNA targets ► Acute and genetic loss of FMRP relieves stalling and increases protein synthesis
Cited by (0)
- 4
Present address: Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA
- 5
Present address: Case Western Reserve University, Center for RNA Molecular Biology, Wood Building, RT100, 10900 Euclid Avenue, Cleveland, OH 44106, USA
Copyright © 2011 Elsevier Inc. All rights reserved.