Cell Reports
Volume 13, Issue 4, 27 October 2015, Pages 657-666
Journal home page for Cell Reports

Report
Striatal Cholinergic Interneurons Control Motor Behavior and Basal Ganglia Function in Experimental Parkinsonism

https://doi.org/10.1016/j.celrep.2015.09.034Get rights and content
Under a Creative Commons license
open access

Highlights

  • CIN activity impacts motor function and basal ganglia output in parkinsonian state

  • CIN inhibition alleviates parkinsonian symptoms, while activation has no effect

  • CIN inhibition corrects burst firing and enhances cortically evoked inhibition in SNr

  • CIN’s control of D2-, but not D1-MSN, excitability is reduced in parkinsonian state

Summary

Despite evidence showing that anticholinergic drugs are of clinical relevance in Parkinson’s disease (PD), the causal role of striatal cholinergic interneurons (CINs) in PD pathophysiology remains elusive. Here, we show that optogenetic inhibition of CINs alleviates motor deficits in PD mouse models, providing direct demonstration for their implication in parkinsonian motor dysfunctions. As neural correlates, CIN inhibition in parkinsonian mice differentially impacts the excitability of striatal D1 and D2 medium spiny neurons, normalizes pathological bursting activity in the main basal ganglia output structure, and increases the functional weight of the direct striatonigral pathway in cortical information processing. By contrast, CIN inhibition in non-lesioned mice does not affect locomotor activity, equally modulates medium spiny neuron excitability, and does not modify spontaneous or cortically driven activity in the basal ganglia output, suggesting that the role of these interneurons in motor function is highly dependent on dopamine tone.

Cited by (0)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

4

Co-first author

5

Co-senior author