Cell Metabolism
Volume 15, Issue 1, 4 January 2012, Pages 38-50
ArticlePGRN is a Key Adipokine Mediating High Fat Diet-Induced Insulin Resistance and Obesity through IL-6 in Adipose Tissue
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Highlights
► PGRN is a key adipokine identified by differential proteome analysis ► PGRN is associated with insulin resistance both in vitro and in vivo ► PGRN mediates systemic insulin resistance by induction of IL-6 in adipose tissues ► Ablation of PGRN prevents HFD-induced insulin resistance and obesity
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These authors contributed equally to this work
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Present address: Division of Molecular Pathology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime 791-0295, Japan
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