Fasting or caloric restriction for Healthy Aging
Section snippets
Future directions
A key issue for future research examining the effects of caloric restriction in humans is whether or not the promising findings from initial human trials translate to non-overweight individuals whose body mass index (BMI; kg/m2) falls in the healthy range (i.e., BMI Range = 20.0 – 24.9 kg/m2). This possibility is currently being explored by the CALERIE Phase 2 study (Rochon et al., 2011). Specifically, the CALERIE Phase 2 study is examining the long-term effects of a 25% reduction of ad libitum
Conflict of interest
The authors have no conflicts of interests.
Acknowledgments
Support was provided by the University of Florida Claude D. Pepper Older Americans Independence Center (NIH/NIA P30AG028740) and the Clinical and Translational Science Institute (NIH/NCRR UL1TR000064). Stephen Anton is supported by a K23 AT004251-01A2, an Early Career Investigator Award from the American Heart Association (09CRP2390173), and Thomas H. Maren Foundation.
References (52)
- et al.
Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast
Exp. Gerontol.
(2013) - et al.
Comparing the effects of food restriction and overeating on brain reward systems
Exp. Gerontol.
(2013) - et al.
Apparent prolongation of the life span of rats by intermittent fasting
J. Nutr.
(1946) - et al.
The effect of fasting on indicators of muscle damage
Exp. Gerontol.
(2013) - et al.
High-fat, energy-dense, fast-food-style breakfast results in an increase in oxidative stress in metabolic syndrome
Metabolism
(2008) - et al.
Maintaining good hearing: Calorie restriction, Sirt3, and glutathione
Am. J. Clin. Nutr.
(2013) - et al.
Calorie restriction and aging: review of the literature and implications for studies in humans
Am. J. Clin. Nutr.
(2003) - et al.
Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction
Mech. Ageing Dev.
(2009) - et al.
Chronic intermittent fasting improves the survival following large myocardial ischemia by activation of BDNF/VEGF/PI3K signaling pathway
J. Mol. Cell. Cardiol.
(2009) - et al.
Resveratrol vs. calorie restriction: Data from rodents to humans
Exp. Gerontol.
(2013)
Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Atherosclerosis
Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction
Mech. Ageing Dev.
Food addiction: Detox and abstinence reinterpreted?
Exp. Gerontol.
Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies
Exp. Gerontol.
Weight loss in obese adults 65 years and older: A review of the controversy
Exp. Gerontol.
Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice
J. Nutr.
Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise
Exp. Gerontol.
Short- and long-term effects of continuous versus intermittent restrictive diet approaches on body composition and the metabolic profile in overweight and obese postmenopausal women: a pilot study
Menopause
Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction
Exp. Gerontol.
Acute hyperglycaemia: a ‘new’ risk factor during myocardial infarction
Eur. Heart J.
Postprandial hyperglycemia and diabetes complications: is it time to treat?
Diabetes
Recent advances in calorie restriction research on aging
Exp. Gerontol.
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
PLoS Med.
Caloric restriction delays disease onset and mortality in rhesus monkeys
Science
Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities
Circ. Res.
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
Proc. Natl. Acad. Sci. U. S. A.
Cited by (84)
Adaptive metabolic response to short-term intensive fasting
2024, Clinical NutritionTherapeutic fasting
2023, Ketogenic: The Science of Therapeutic Carbohydrate Restriction in Human HealthNutrition and upper gastrointestinal cancers: An overview of current understandings
2022, Seminars in Cancer BiologyUse of Minimally Invasive Methods to Assess Fuel Utilization and Circadian Rhythms in Older Adults
2024, Journal of Visualized Experiments