Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice
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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain
2010, Journal of Lipid ResearchReelin-mediated signaling in neuropsychiatric and neurodegenerative diseases
2010, Progress in Neurobiologyβ-amyloid controls altered Reelin expression and processing in Alzheimer's disease
2010, Neurobiology of DiseaseCitation Excerpt :First, Reelin competes with apolipoprotein E (ApoE) for binding to the ApoE receptors, ApoER2 and VLDLR (D'Arcangelo et al., 1999; Hiesberger et al., 1999), and ApoE ɛ4, the major known genetic risk factor for AD, is one of the strongest competitors (D'Arcangelo et al., 1999). A direct role for ApoER2 on amyloid deposition and neurodegeneration in AD has also been suggested (Motoi et al., 2004). In addition, Reelin receptors convey intracellular signals through the adaptor Dab1 (Bar and Goffinet, 1999;Cooper and Howell, 1999; Trommsdorff et al., 1999), thereby leading to a signaling cascade that ultimately controls glycogen synthase kinase-3β (GSK-3β) (Beffert et al., 2002), an enzyme that regulates phosphorylation of the microtubule binding protein tau.
Age-related accumulation of Reelin in amyloid-like deposits
2009, Neurobiology of AgingCitation Excerpt :To the best of our knowledge, no data are available on the existence of Reelin-positive accumulations in the hippocampal formation of wild-type mice, rats, non-human primates or humans. Three studies described Reelin- and ApoER2-IR, respectively, in neuritic compartments of Aβ plaques in transgenic AD mice (Miettinen et al., 2005; Motoi et al., 2004; Wirths et al., 2001). It is unclear, however, whether they were associated with non-fibrillary or fibrillary plaques.
Lipid Peroxidation Induced ApoE Receptor-Ligand Disruption as a Unifying Hypothesis Underlying Sporadic Alzheimer's Disease in Humans
2022, Journal of Alzheimer's Disease