Elsevier

Neuroscience Letters

Volume 372, Issues 1–2, 30 November 2004, Pages 127-131
Neuroscience Letters

Time dependent alterations in dopamine tissue levels and metabolism after experimental traumatic brain injury in rats

https://doi.org/10.1016/j.neulet.2004.09.026Get rights and content

Abstract

Several studies have demonstrated alterations in the dopamine (DA) system after traumatic brain injury (TBI). The present study investigated the temporal changes in DA tissue levels and metabolism at 1-h or 1, 7, 14, and 28 days after cortical impact or sham injury in rats. DA and DOPAC levels were measured by HPLC in the frontal cortex (FC) and striatum. DA levels were significantly increased at 1 h in the contralateral FC and at 1 day in the ipsilateral FC versus respective sham groups. DA and DOPAC levels were significantly increased bilaterally at 1 h in the striatum versus sham. These data indicate that TBI induces an early increase in DA and DOPAC, which returns to sham levels over time.

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Acknowledgment

This work was supported by NIH grants NS40125 and NS303180 (C.E.D.) and HD043851 (A.E.K.).

References (23)

  • F. Huger et al.

    Effect of concussive head injury on central catecholamine levels and synthesis rates in rat brain regions

    J. Neurochem.

    (1979)
  • Cited by (0)

    1

    Present address: Drexel University School of Medicine, Philadelphia, PA, USA.

    2

    These data were a partial fulfilment of the requirements for a neuroscience honors thesis (J.L.M.).

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