Transient expression of hypoxia-inducible factor-1 alpha and target genes in peripheral nerves from diabetic rats
Section snippets
Acknowledgments
The authors thank Rafael Mattera for helpful discussions and revision of the manuscript. This work was supported by grants DK064465 from the National Institutes of Health and 464-B-01 from the Diabetes Association of Greater Cleveland to L.N.B.-M.
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Preparation, characterization, and pharmacological application of oral Honokiol-loaded solid lipid nanoparticles for diabetic neuropathy
2023, International Journal of PharmaceuticsHyperglycemia-induced degradation of HIF-1α contributes to impaired response of cardiomyocytes to hypoxia
2017, Revista Portuguesa de CardiologiaCitation Excerpt :The cellular response to hypoxia is a complex process that involves activation of HIF-1α, which eventually leads to increased transcription of genes that help cells to cope with low oxygen levels. It is well established, for various cell types and tissues, that in diabetic conditions the degradation of HIF-1α is increased in hypoxic conditions, thus compromising cells’ ability to adapt and survive.2,19–23 However, the effect of MGO on cardiac cells’ response to low oxygen tension is still unclear.
Role of Hypoxia Inducible Factor 1 in Hyperglycemia-Exacerbated Blood-Brain Barrier Disruption in Ischemic Stroke
2016, Neurobiology of DiseaseCitation Excerpt :Our present report is the first to demonstrate that HIF-1α is up-regulated in the brain microvessels of diabetic stroke mice. This is in line with many recent findings in other tissues such as hearts (Marfella et al., 2002), peripheral nerves (Chavez et al., 2005), pancreas (Haligur et al., 2012), retina (Ly et al., 2011), and kidney glomeruli (Isoe et al., 2010). Studies based on samples from human diabetic patients have also shown increased HIF-1α levels in pre-retinal membranes (Lim et al., 2010) and vitreous fluid (Wang et al., 2009).
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
2011, Biochemical and Biophysical Research CommunicationsCitation Excerpt :On the other hand, our present findings clearly displayed a drastic reduction of HIF-1α protein by exposure to HFSD for 20 weeks. This is in a good agreement with a report by Chavez et al. showing a transient increase in HIF-1α in nerve tissues from streptozotocin-evoked diabetic rats [16]. Islet HIF-1α expression has been recently reported to decrease in both human and mice of type 2 diabetes [17].
Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC
2011, PainCitation Excerpt :In order to find out a mechanism through which hypoxia can sensitize TRPV1, contribution of the transcriptional regulator HIF-1α was examined. HIF-1α is known to accumulate rapidly under hypoxic conditions and modulate the expression of several target gene transcripts that protect tissues against ischemia and infarction, including GLUT1 gene [7,50]. It was also reported that hyperglycemia impaired hypoxia-dependent protection of HIF-1α against proteosomal degradation, suggesting a mechanism by which diabetes interferes with cellular responses to hypoxia [6].
Effects of medications on hypoxia-inducible factor in the retina: A review
2023, Clinical and Experimental Ophthalmology
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Present address: Department of Molecular Neurobiology, Burke/Cornell Medical Research Institute, 785 Mamaroneck Ave, White Plains, NY 10605, USA.