Propofol-mediated impairment of CA1 long-term potentiation in mouse hippocampal slices
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Cited by (38)
The effects of repeated propofol anesthesia on spatial memory and long-term potentiation in infant rats under hypoxic conditions
2020, Genes and DiseasesCitation Excerpt :Meanwhile, we also found that propofol per se induced short-term cognitive impairment; however, propofol in combination with hypoxia severely impaired cognitive function in newborn rats. Additionally, propofol causes LTP impairment.7–11 LTP, which is believed to involve mechanisms that underlie memory formation, has been studied most extensively in the hippocampus.12,13
The recovery from transient cognitive dysfunction induced by propofol was associated with enhanced autophagic flux in normal healthy adult mice
2018, Brain ResearchCitation Excerpt :Propofol acts as a gamma-aminobutyric acid A (GABAA) receptor agonist and an N-methyl-d-aspartate receptor (NMDAR) antagonist. The action of propofol in the hippocampus during and after anesthesia alters long-term potentiation (LTP), resulting in changes to synaptic plasticity (Gao et al., 2014; Nagashima et al., 2005; Takamatsu et al., 2005). LTP inhibition, paralleled with reduced expression of the phosphorylated alpha-isoform of Calcium (Ca2+)/calmodulin-dependent protein kinase II (pCaMKIIα) and associated learning and cognitive function, has been observed in young rats following repetitive administration of propofol (Gao et al., 2014).
Detrimental effects of postnatal exposure to propofol on memory and hippocampal LTP in mice
2015, Brain ResearchCitation Excerpt :Among the different types of plasticity, long-term potentiation (LTP) is still the typical cellular model for learning and memory, while long-term depression is thought to correlate with memory consolidation and retrieve (Ge et al., 2010). There were studies suggesting that LTP was impaired in adult animals after propofol application (Takamatsu et al., 2005; Wang et al., 2006; Wei et al., 2002), which was correlated with the memory decrease. However, long-term effects of postnatal propofol application on hippocampal synaptic plasticity, especially the underlying mechanisms are still not disclosed.