Effect of in vivo striatal perfusion of lipopolysaccharide on dopamine metabolites
Section snippets
Acknowledgements
This study was supported by Grant SAF2007-62425 from Spanish Government. R.M. thanks the Spanish Ministerio de Educación y Ciencia for an FPI fellowship.
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2020, Brain, Behavior, and Immunity - HealthCitation Excerpt :Direct evidence for a causal link was provided by data from melanoma patients receiving interferons therapies (IFN; a pro-inflammatory cytokine family), where CRF gradually developed in the weeks following therapy initiation (Capuron et al., 2002). Mechanistic insights from neuroimaging studies (Capuron et al., 2007, 2012) and animal models (Mauriño et al., 2010; Qin et al., 2007) showed that administration of IFN-α or lipopolysaccharide (LPS; which induces a systemic inflammatory response) upregulates the neuroinflammatory activity and dysregulates the dopaminergic metabolism of the basal ganglia, leading to fatigue or anhedonic behaviors (reviewed in Felger and Miller, 2012). One suspected mechanism linking systemic inflammation to CRF is the inflammatory-induced upregulation of indoleamine 2,3 dioxygenase (IDO) activity.
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2016, Journal of NeuroimmunologyCitation Excerpt :Subsequently, the rats were perfused for an hour by saline containing LPS in concentration of 1 mg/ml. The LPS concentration and a flow rate of 0.5 μl/min was based on previous study by Mauriño et al. (2010). The control group was perfused by saline with a flow rate of 0.5 μl/min.
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2016, Journal of NeuroimmunologyCitation Excerpt :GABA was also marginally, but significantly increased at the end of experiment (Fig. 1B), indicating an effort of compensatory response to maintain the balance between GLU and GABA. In accordance with previous findings (Lavicky and Dunn, 1995, Maurino et al., 2010), LPS treatment increased the extracellular levels of DA (Fig. 1D) and its metabolites, HVA (Fig. 1F), but didn't affect the concentrations of 3,4-dihydroxyphenylacetic acid (DOPAC) (Fig. 1E). LPS had no effect on the extracellular levels of norepinephrine (NE) and its major metabolites, vanillylmandelic acid (VMA) and 3-Methoxy-4-hydroxyphenylglycol (MHPG) (Fig. 1G, H and I).
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2015, Neurochemistry InternationalCitation Excerpt :Further, significant (p ≥ 0.001) decline of more than 50% in the level of dopamine and subsequent decrease in the level of its metabolites HVA and DOPAC were seen following LPS injection. Above mentioned results were further supported by the study of Maurino et al. (2010) who reported a dose dependent decrease in level of dopamine in LPS PD model. Thus, this marked decrease in the number of dopaminergic neurons and substantial decline in the level of dopamine following LPS injection is sufficient for the appearance of behavioral abnormality in rats.
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2012, Frontiers in NeuroendocrinologyCitation Excerpt :Indeed, both HIV and peripheral administration of IFN-alpha have been associated with a central inflammatory response (Gray et al., 1996; Raison et al., 2009). Moreover, infusion of LPS to selectively activate microglia in the striatum has been shown to reduce extracellular DOPAC as measured by in vivo microdialysis (Maurino et al., 2010). Taken together, these findings support a role for dopamine function in fatigue, psychomotor slowing, and sleep alterations associated with IFN-alpha and medical illness involving CNS inflammation and prompt further investigation into inflammation effects on dopamine function and the basal ganglia.