Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain
Graphical abstract
Research highlights
▶ FK506 increases basal dendritic spine density on layer II–III pyramidal neurons. ▶ FK506 increases branching of basal dendritic tree of layer II–III pyramidal neurons. ▶ Calcineurin inhibition changes branching and spine density in healthy adult brain.
Section snippets
Acknowledgements
This work was supported by NIH grants K99 AG033670-01A1, P50 AG005134, AG08487, and the Alzheimer's Disease Drug Discovery Foundation/Association for Frontotemporal Dementias.
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