Quadri-pulse stimulation (QPS) induced LTP/LTD was not affected by Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene
Research highlights
▶ QPS induces bidirectional plastic changes in the human motor cortex. ▶ QPS induces LTP/LTD similarly in any types of Val66Met BDNF polymorphism. ▶ QPS is superior to other stimulations because it is unaffected by the BDNF polymorphism. ▶ QPS may have much clinical utility because of its stable long term effects.
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Disclosures statement
This work is partly supported by Research Project Grants-in-aid for Scientific Research No. 20591019(RH) and No. 22390181 (YU), the Ministry of Education, Culture, Sports, Science, and Technology of Japan; the Research Committee on best rTMS Treatment of Parkinson's Disease, the Ministry of Health and Welfare of Japan (RH, YU); the Research Committee on Dystonia, the Ministry of Health and Welfare of Japan (YU); the Committee of the Study of Human Exposure to EMF, Ministry of Public Management,
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