Neuron
Volume 54, Issue 1, 5 April 2007, Pages 1-3
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Two Wrongs Make a Right: Deficits in Reversal Learning after Orbitofrontal Damage Are Improved by Amygdala Ablation

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Impaired cognitive flexibility after orbitofrontal damage has informed theories of orbitofrontal function and prefrontal cortex function generally. In this issue of Neuron, Stalnaker et al. demonstrate that reversal learning deficits after orbitofrontal damage in rats are eliminated by additional lesions of the basolateral amygdala. The involvement of orbitofrontal cortex in cognitive flexibility is via its interaction with the amygdala, and perhaps other brain areas, rather than an intrinsic property of this cortical region.

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Correspondence: Mark Baxter, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, United Kingdom.