Neuron
Volume 56, Issue 1, 4 October 2007, Pages 33-42
Journal home page for Neuron

Review
Perisomatic Inhibition

https://doi.org/10.1016/j.neuron.2007.09.012Get rights and content
Under an Elsevier user license
open archive

Recent evidence supports the hypothesis of a functional dichotomy of perisomatic inhibition in the cerebral cortex: the parvalbumin- and cholecystokinin-containing basket cells that are specialized to control rhythm (as a clockwork) and “mood” (as a fine-tuning device), respectively, of network oscillations. Pathology extends this conclusion further, as the former is implicated in epilepsy and the latter in anxiety. The well-balanced cooperation of the two inhibitory systems is required for the normal network operations underlying the cognitive functions of the cerebral cortex.

Cited by (0)