Neuron
Volume 96, Issue 5, 6 December 2017, Pages 1192-1203.e4
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Article
Lateral Orbitofrontal Inactivation Dissociates Devaluation-Sensitive Behavior and Economic Choice

https://doi.org/10.1016/j.neuron.2017.10.026Get rights and content
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Highlights

  • Rats perform an economic choice task previously used in primates

  • Rats choose between two rewards that vary in flavor and number on each trial

  • Optogenetic inactivation of the OFC has no effect on economic choice behavior

  • In the same rats, optogenetic inactivation disrupts devaluation-sensitive behavior

Summary

How do we choose between goods that have different subjective values, like apples and oranges? Neuroeconomics proposes that this is done by reducing complex goods to a single unitary value to allow comparison. This value is computed “on the fly” from the underlying model of the goods space, allowing decisions to meet current needs. This is termed “model-based” behavior to distinguish it from pre-determined, habitual, or “model-free” behavior. The lateral orbitofrontal cortex (OFC) supports model-based behavior in rats and primates, but whether the OFC is necessary for economic choice is less clear. Here we tested this question by optogenetically inactivating the lateral OFC in rats in a classic model-based task and during economic choice. Contrary to predictions, inactivation disrupted model-based behavior without affecting economic choice.

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