NeuropharmacologyD1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
Section snippets
Animals and housing
Male Sprague–Dawley rats (Rattus norvegicus) weighing 250–300g were obtained from Taconic Laboratories (Germantown, NY, USA). Animals were individually housed with food and water available ad libitum. A 12-h light/dark cycle was used with the lights on at 7:00 A.M.; all experiments were performed during the light cycle. All experimental procedures were consistent with the ethical guidelines of the U.S. National Institutes of Health and were approved by the Boston University School of Medicine
Cannula placements in the nucleus accumbens
The cannula placements in the nucleus accumbens from the experiments outlined in this chapter are shown in Fig. 1. The accumbal placements were aimed at the medial limb of the nucleus accumbens shell (filled circles) or the area surrounding the anterior commissure, which corresponds to the central nucleus accumbens core (empty circles). There were 21 successful bilateral core placements and 28 successful shell placements. Data from three core and four shell targets were removed from the
Discussion
Previous research indicates that administration of the D1/D5 dopamine receptor antagonist, SCH-23390, into the nucleus accumbens generally (Maldonado et al 1993, McGregor and Roberts 1993) and the shell subregion of the nucleus accumbens specifically (Maldonado et al 1993, Caine et al 1995) decreases the reinforcing efficacy of cocaine in rats. The first series of the present experiments were designed to assess the role of D1/D5 dopamine receptors in both the nucleus accumbens shell and core in
Acknowledgments
This work was supported by a grant from the U.S. National Institutes of Health to R.C.P. (R01 DA15214) as well as pre-doctoral MD-PhD National Research Service Award to A.A.B. (F30 DA14205).
References (61)
- et al.
A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement
Pharmacol Biochem Behav
(1997) - et al.
Relative activities of SCH 23390 and its analogs in three tests for D1/DA1 dopamine receptor antagonism
Eur J Pharmacol
(1986) - et al.
Turning in rats following intraaccumbens shell injections of amphetamine or eticlopride
Pharmacol Biochem Behav
(2000) - et al.
Serotonin receptor blocking effect of SCH 23390
Pharmacol Biochem Behav
(1989) - et al.
Neostriatal dopamine receptors
Trends Neurosci
(1994) - et al.
Effects of remoxipride, an atypical antipsychotic, on cocaine self-administration in the rat using fixed- and progressive-ratio schedules of reinforcement
Drug Alcohol Depend
(1995) - et al.
Parameters of self-administration of cocaine in rats under a progressive-ratio schedule
Pharmacol Biochem Behav
(1993) - et al.
Dopamine and drug addictionthe nucleus accumbens shell connection
Neuropharmacology
(2004) - et al.
Targeting the dopamine D3 receptor cannot influence continuous reinforcement cocaine self-administration in rats
Brain Res Bull
(2003) - et al.
Effect of nucleus accumbens dopamine depletion on motivational aspects involved in initiation of cocaine and heroin self-administration in rats
Brain Res
(1996)
Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbensan in vivo microdialysis study
Brain Res
Dopamine D5 receptors of rat and human brain
Neuroscience
Drug addiction, dysregulation of reward, and allostasis
Neuropsychopharmacology
Interactions of the novel antipsychotic aripiprazole (OPC-14597) with dopamine and serotonin receptor subtypes
Neuropsychopharmacology
D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat
Pharmacol Biochem Behav
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques
Neuroscience
Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement
Brain Res
Distribution of D5 dopamine receptor mRNA in rat brain
Neurosci Lett
Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures
Neuropsychopharmacology
Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis
Pharmacol Biochem Behav
Progressive ratio schedules in drug self-administration studies in ratsa method to evaluate reinforcing efficacy
J Neurosci Methods
A single injection of either flupenthixol decanoate or haloperidol decanoate produces long-term changes in cocaine self-administration in rats
Drug Alcohol Depend
Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens
Pharmacol Biochem Behav
Molecular biology of dopamine receptors
Trends Pharmacol Sci
An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
Neurosci Biobehav Rev
Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats
Psychopharmacology (Berl)
Highlights of D1 dopamine receptor antagonist research
Neurochem Int
Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys
J Neurosci
Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat
Brain Res
Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food
J Exp Anal Behav
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2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :In addition, systemic administration of DA receptor antagonists attenuates cocaine, amphetamine, heroin or oxycodone reward, as assessed in various drug-self administration paradigms (de Wit and Wise, 1977; Galaj et al., 2016, 2014; Song et al., 2011; You et al., 2018). Similar effects have been observed after intra-NAc injections of DA antagonists (Bari and Pierce, 2005; Caine et al., 1995; Phillips et al., 1994) or optogenetic inhibition of VTA DA neurons (Corre et al., 2018; Galaj et al., 2020), suggesting that the mesolimbic DA system is critically involved in drug reward. It is also well-established that stimuli that are associated with primary rewards (e.g., drug paraphernalia) come to possess the ability to activate the mesocorticolimbic DA system to some degree.
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2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Studies with intracranial injections have localized the sites of D1-like receptor antagonist action within the mesocorticolimbic regions. Intracranial injections of SCH 23390 into the NAcc shell and core, central amygdala, dorsolateral bed nucleus of the stria terminalis (dlBNST), substantia nigra, and medial prefrontal cortex (mPFC), but not posterior caudate nucleus, dorsal striatum, neostriatum or lateral septum increased self-administration of cocaine, which reflects a decrease in the magnitude of reward (Bari and Pierce, 2005; Caine et al., 1995; Epping-Jordan et al., 1998; Maldonado et al., 1993; McGregor and Roberts, 1993; 1995; Quinlan et al., 2004). The role of D1 receptors in reward has been also demonstrated in studies using multiple schedules of reinforcement, where two or more reinforcement schedules are typically presented one at a time in an alternating sequence each day, and each schedule component is associated with different discriminative stimuli and rewards.