D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement

doi:10.1016/j.neuroscience.2005.06.048

Neuroscience

Volume 135, Issue 3, 2005, Pages 959-968

https://doi.org/10.1016/j.neuroscience.2005.06.048 Get rights and content

Abstract

Cocaine self-administration experiments were designed to assess the respective roles of D1-like and D2-like dopamine receptors in the ventral forebrain in cocaine reinforcement. D1-like or D2-like dopamine receptor antagonists were microinjected into the nucleus accumbens core, nucleus accumbens shell, neostriatum or lateral septum prior to sessions in which cocaine was self-administered under a progressive ratio schedule by rats. The results indicated that administration of a D1/5 (SCH-23390) or a D2/D3/D4 (eticlopride), but not a D3 (U99194A) or D4 (L-750,667), dopamine receptor antagonist into the core and shell of the nucleus accumbens decreased the reinforcing efficacy of cocaine. However, in control experiments intra-accumbal core administration of SCH-23390 or eticlopride decreased food self-administration, whereas administration of these drugs into the accumbens shell had no effect on food reinforcement. Neither SCH-23390 nor eticlopride influenced cocaine reinforcement when administered into the neostriatum or lateral septum. Collectively, these results indicate that D1-like and D2 dopamine receptors in the nucleus accumbens shell selectively modulate the reinforcing efficacy of cocaine, whereas D1-like and D2 dopamine receptors in the accumbens core have a more general influence on reinforced behaviors.

Section snippets

Animals and housing

Male Sprague–Dawley rats (Rattus norvegicus) weighing 250–300g were obtained from Taconic Laboratories (Germantown, NY, USA). Animals were individually housed with food and water available ad libitum. A 12-h light/dark cycle was used with the lights on at 7:00 A.M.; all experiments were performed during the light cycle. All experimental procedures were consistent with the ethical guidelines of the U.S. National Institutes of Health and were approved by the Boston University School of Medicine

Cannula placements in the nucleus accumbens

The cannula placements in the nucleus accumbens from the experiments outlined in this chapter are shown in Fig. 1. The accumbal placements were aimed at the medial limb of the nucleus accumbens shell (filled circles) or the area surrounding the anterior commissure, which corresponds to the central nucleus accumbens core (empty circles). There were 21 successful bilateral core placements and 28 successful shell placements. Data from three core and four shell targets were removed from the

Discussion

Previous research indicates that administration of the D1/D5 dopamine receptor antagonist, SCH-23390, into the nucleus accumbens generally (Maldonado et al 1993, McGregor and Roberts 1993) and the shell subregion of the nucleus accumbens specifically (Maldonado et al 1993, Caine et al 1995) decreases the reinforcing efficacy of cocaine in rats. The first series of the present experiments were designed to assess the role of D1/D5 dopamine receptors in both the nucleus accumbens shell and core in

Acknowledgments

This work was supported by a grant from the U.S. National Institutes of Health to R.C.P. (R01 DA15214) as well as pre-doctoral MD-PhD National Research Service Award to A.A.B. (F30 DA14205).

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NeuropharmacologyD1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement

Abstract

Section snippets

Animals and housing

Cannula placements in the nucleus accumbens

Discussion

Acknowledgments

Pharmacol Biochem Behav

Eur J Pharmacol

Pharmacol Biochem Behav

Pharmacol Biochem Behav

Trends Neurosci

Drug Alcohol Depend

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Neuropharmacology

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Neuropsychopharmacology

Neuropsychopharmacology

Pharmacol Biochem Behav

Neuroscience

Brain Res

Neurosci Lett

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Pharmacol Biochem Behav

J Neurosci Methods

Drug Alcohol Depend

Pharmacol Biochem Behav

Trends Pharmacol Sci

Neurosci Biobehav Rev

Administration of the D1-like dopamine receptor antagonist SCH-23390 into the medial nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug-seeking behavior in rats

Psychopharmacology (Berl)

Highlights of D1 dopamine receptor antagonist research

Neurochem Int

Impact of self-administered cocaine and cocaine cues on extracellular dopamine in mesolimbic and sensorimotor striatum in rhesus monkeys

J Neurosci

Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat

Brain Res

Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food

J Exp Anal Behav

Neuropharmacology
D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement