Systems neuroscienceThalamocortical and the dual pattern of corticothalamic projections of the posterior parietal cortex in macaque monkeys
Section snippets
Experimental procedures
The present study was conducted on two adult macaque monkeys (one Macaca mulatta and one Macaca fascicularis), 3 and 4 years old and weighing 3 and 4 kg. Surgical procedures and animal care were conducted in accordance with the Guide for Care and Use of Laboratory Animals (ISBN 0-309-05377-3; 1996) and were approved by local (Swiss) veterinary authorities. Experimental procedures were designed to minimize the animals’ pain and suffering.
Localization of injections sites
Area PE occupies the surface of rostral superior parietal lobule whereas area PEa is located in the upper bank of the IPS (Paxinos et al., 2000). The distinction between areas PE and PEa is based on cytoarchitectonic criteria as initially defined in Nissl material by Pandya and Seltzer (1982) and reported later in other studies (Seltzer and Pandya 1984, Seltzer and Pandya 1986, Matelli et al 1998). In line with these data (Pandya and Seltzer, 1982), Nissl-stained sections adjacent to the
Location of injection sites
Two distinct sub-areas of the posterior parietal cortex were injected in the superior parietal lobule. The region injected in the anterior bank of IPS corresponds to area PEa (named also area 5v) whereas the region injected in the anterior bank surface of IPS is area PE (named also area 5d), as referred to in previous studies (Pandya and Seltzer 1982, Seltzer and Pandya 1984, Seltzer and Pandya 1986, Matelli et al 1998).
Topography of TC projections
The distributions and relative proportions of labeled cells in different
Conclusion
In conclusion, the present study supports the notion that area 5 in the macaque monkey comprises two cytoarchitectonally distinct sub-areas, PE and PEa, as assessed in Nissl- and SMI-32 stained material. The areas PE and PEa have largely comparable patterns of TC and CT projections, mainly with the caudal thalamus, more specifically with the nuclei LP, PuM and VPL. The thalamic territories projecting to areas PE and PEa overlap to a significant extent, as much as those directed to the two
Acknowledgments
The authors wish to thank technical assistance of Véronique Moret, Georgette Fischer, Françoise Tinguely, Christine Roulin and Veronika Streit (histology), Josef Corpataux, Bernard Bapst, Laurent Bossy and Bernard Morandi (animal housekeeping), Laurent Monney (informatics).
Grant Sponsors: Swiss National Science Foundation, grants No. 31-61857.00, 310000-110005 (E.M.R.), Novartis Foundation; The Swiss National Science Foundation Centre of Competence in Research (NCCR) on “Neural plasticity and
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1.33 - Visual-Motor Integration in the Primate Brain
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